Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS

Background. The compilation of previous genomewide association studies of AIDS shows a major polymorphism in the HCP5 gene associated with both control of the viral load and long-term nonprogression (LTNP) to AIDS. Methods. To look for genetic variants that affect LTNP without necessary control of t...

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Published in:The Journal of infectious diseases 2010-09, Vol.202 (6), p.908-915
Main Authors: Limou, Sophie, Coulonges, Cédric, Herbeck, Joshua T., van Manen, Daniëlle, An, Ping, Le Clerc, Sigrid, Delaneau, Olivier, Diop, Gora, Taing, Lieng, Montes, Matthieu, van't Wout, Angélique B., Gottlieb, Geoffrey S., Therwath, Amu, Rouzioux, Christine, Delfraissy, Jean-François, Lelièvre, Jean-Daniel, Lévy, Yves, Hercberg, Serge, Dina, Christian, Phair, John, Donfield, Sharyne, Goedert, James J., Buchbinder, Susan, Estaquier, Jérôme, Schächter, François, Gut, Ivo, Froguel, Philippe, Mullins, James I., Schuitemaker, Hanneke, Winkler, Cheryl, Zagury, Jean-François
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - genetics
Acquired Immunodeficiency Syndrome - immunology
AIDS
Biological and medical sciences
Cohort Studies
Computer software
Genetic Association Studies
Genomics
Haplotypes
HIV 1
HIV Long-Term Survivors
HIV/AIDS
Human genetics
Human viral diseases
Humans
Immunity, Innate
Infections
Infectious diseases
Major and Brief Reports
Male
Medical genetics
Medical sciences
Polymorphism, Genetic
Receptors, Chemokine - genetics
Receptors, Chemokine - immunology
Receptors, CXCR6
Receptors, Virus - genetics
Receptors, Virus - immunology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral load
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Summary:Background. The compilation of previous genomewide association studies of AIDS shows a major polymorphism in the HCP5 gene associated with both control of the viral load and long-term nonprogression (LTNP) to AIDS. Methods. To look for genetic variants that affect LTNP without necessary control of the viral load, we reanalyzed the genomewide data of the unique LTNP Genomics of Resistance to Immunodeficiency Virus (GRIV) cohort by excluding “elite controller” patients, who were controlling the viral load at very low levels (
ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1086/655782