Sterile inflammatory responses mediated by the NLRP3 inflammasome

Through pattern recognition receptors the innate immune system detects disruption of the normal function of the organism and initiates responses directed at correcting these derangements. Cellular damage from microbial or non‐microbial insults causes the activation of nucleotide‐binding domain leuci...

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Bibliographic Details
Published in:European journal of immunology 2010-03, Vol.40 (3), p.607-611
Main Authors: Cassel, Suzanne L., Sutterwala, Fayyaz S.
Format: Article
Language:English
Subjects:
Animals
Carrier Proteins - immunology
Caspase‐1
Danger signals
Humans
Inflammation - immunology
Multiprotein Complexes - immunology
Necrosis
NLR Family, Pyrin Domain-Containing 3 Protein
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Summary:Through pattern recognition receptors the innate immune system detects disruption of the normal function of the organism and initiates responses directed at correcting these derangements. Cellular damage from microbial or non‐microbial insults causes the activation of nucleotide‐binding domain leucine‐rich repeat containing receptors in multiprotein complexes called inflammasomes. Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.200940207