IL-33 promotes eosinophilia in vivo and antagonizes IL-5-dependent eosinophil hematopoiesis ex vivo

Highlights ► IL-33 mediated eosinophil hematopoiesis is IL-5 dependent in vivo . ► IL-33 antagonizes the effects of IL-5 in vitro and inhibits IL-5 dependent eosinophil differentiation. ► The autocrine release of GM-CSF in IL-33 treated cultures mediates, in part, the IL-33 inhibition of IL-5 depend...

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Bibliographic Details
Published in:Immunology letters 2013-02, Vol.150 (1), p.41-47
Main Authors: Dyer, Kimberly D, Percopo, Caroline M, Rosenberg, Helene F
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Bone Marrow Cells - drug effects
Cell Differentiation - drug effects
Cells, Cultured
Cytokines - metabolism
Eosinophil
Eosinophilia - chemically induced
Eosinophils - cytology
Eosinophils - drug effects
Eosinophils - metabolism
GM-CSF
Granulocyte-Macrophage Colony-Stimulating Factor - metabolism
IL-33
IL-5
Interleukin-33
Interleukin-5 - administration & dosage
Interleukin-5 - pharmacology
Interleukins - administration & dosage
Interleukins - adverse effects
Interleukins - pharmacology
Mice
Myelopoiesis - drug effects
Myelopoiesis - physiology
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Summary:Highlights ► IL-33 mediated eosinophil hematopoiesis is IL-5 dependent in vivo . ► IL-33 antagonizes the effects of IL-5 in vitro and inhibits IL-5 dependent eosinophil differentiation. ► The autocrine release of GM-CSF in IL-33 treated cultures mediates, in part, the IL-33 inhibition of IL-5 dependent eosinophil differentiation.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2012.12.002