Mitochondrial Network Size Scaling in Budding Yeast

Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occur...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2012-11, Vol.338 (6108), p.822-824
Main Authors: Rafelski, Susanne M., Viana, Matheus P., Zhang, Yi, Chan, Yee-Hung M., Thorn, Kurt S., Yam, Phoebe, Fung, Jennifer C., Li, Hao, da F. Costa, Luciano, Marshall, Wallace F.
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Budding
Cell growth
Cells
Cellular biology
Cellular metabolism
Fundamental and applied biological sciences. Psychology
G1 Phase
Genetics
Life span
Microscopy, Confocal
Mitochondria
Mitochondria - metabolism
Mitochondria - ultrastructure
Mitochondrial genes
Mitochondrial Size
Molecular and cellular biology
Mother cells
Mothers
rab GTP-Binding Proteins - genetics
rab GTP-Binding Proteins - metabolism
Saccharomyces cerevisiae
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - growth & development
Saccharomyces cerevisiae - ultrastructure
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Saccharomycetales
Yeast
Yeasts
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Summary:Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all buds attained the same average ratio. Thus, yeast populations achieve a stable scaling relation between mitochondrial content and cell size despite asymmetry in inheritance.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1225720