Identification of potential targets in Staphylococcus aureus N315 using computer aided protein data analysis

Staphylococcus aureus is a gram positive bacterium, responsible for both community-acquired and hospital-acquired infection, resulting in a mortality rate of 39%. 43.2% resistance to methicilin and emerging resistance to Fluroquinolone and Oxazolidinone, have evoked the necessity of the establishmen...

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Bibliographic Details
Published in:Bioinformation 2013-01, Vol.9 (4), p.187-192
Main Authors: Hossain, Mehjabeen, Chowdhury, Dil Umme Salma, Farhana, Jacy, Akbar, Mohammed Touaha, Chakraborty, Ananya, Islam, Shamima, Mannan, Adnan
Format: Article
Language:English
Subjects:
Computer applications
Hypothesis
Staphylococcus aureus
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Summary:Staphylococcus aureus is a gram positive bacterium, responsible for both community-acquired and hospital-acquired infection, resulting in a mortality rate of 39%. 43.2% resistance to methicilin and emerging resistance to Fluroquinolone and Oxazolidinone, have evoked the necessity of the establishment of alternative and effective therapeutic approach to treat this bacteria. In this computational study, various database and online software are used to determine some specific targets of Staphylococcus aureus N315 other than those used by Penicillin, Quinolone and Oxazolidinone. For this purpose, among 302 essential proteins, 101 nonhomologous proteins were accrued and 64 proteins which are unique in several metabolic pathways of S. aureus were isolated by using metabolic pathway analysis tools. Furthermore, 7 essentially unique enzymes involved in exclusive metabolic pathways were revealed by this research, which can be potential drug target. Along with these important enzymes, 15 non-homologous proteins located on membrane were identified, which can play a vital role as potential therapeutic targets for the future researchers.
ISSN:0973-2063
0973-8894
0973-2063
DOI:10.6026/97320630009187