Anti-S antibodies: an unusual cause of haemolytic disease of the fetus and newborn (HDFN)

We report a case of haemolytic disease of the fetus and newborn due to anti-S antibodies. Baby G was born by emergency caesarean section at 35 weeks due to reduced fetal movement. Prior to delivery, antenatal screening revealed the mother's blood group was AB rhesus positive with anti-S antibod...

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Bibliographic Details
Published in:BMJ case reports 2013-01, Vol.2013, p.bcr2012006547
Main Authors: Pitan, Christopher, Syed, Azhar, Murphy, W, Akinlabi, Oluwafemi, Finan, Alan
Format: Article
Language:English
Subjects:
Anemia
Antibiotics
Antibodies
Antigens
Autoantibodies - immunology
Babies
Blood groups
Blood transfusions
Erythroblastosis, Fetal - immunology
Europe (West)
Female
Fetuses
Hemoglobin
Hepatitis
Humans
Immunoglobulins
Infant, Newborn
Light therapy
Neonate
Protein S - immunology
Rubella
Unusual Presentation of More Common Disease/Injury
White
Womens health
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Summary:We report a case of haemolytic disease of the fetus and newborn due to anti-S antibodies. Baby G was born by emergency caesarean section at 35 weeks due to reduced fetal movement. Prior to delivery, antenatal screening revealed the mother's blood group was AB rhesus positive with anti-S antibody titres. The baby was pale but non-hydropic at birth with hepatosplenomegaly. Haemoglobin at birth was 5.23 g/dl and serum bilirubin 138 µmol/l. The baby required phototherapy, γ-globulin infusion and exchange transfusion with post-transfusion complications.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2012-006547