An unusual cause of severe persistent neutropenia in a child with nephrotic syndrome

A 5-year-old boy presented with neutropenia 9 weeks following the administration of rituximab for management of his steroid-dependent nephrotic syndrome. Extensive investigations failed to identify any underlying cause. In keeping with adult reports, rituximab was thought to be the likely cause for...

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Bibliographic Details
Published in:BMJ case reports 2013-01, Vol.2013, p.bcr2012007958
Main Authors: Kshirsagar, Archana A, Reid, Christopher J D, Alamelu, Jayanthi, Sinha, Manish D
Format: Article
Language:English
Subjects:
Antibiotics
Antibodies, Monoclonal, Murine-Derived - adverse effects
Bone marrow
Child, Preschool
Drug dosages
Fever
Granulocyte Colony-Stimulating Factor - therapeutic use
Granulocytes
Humans
Immunologic Factors - adverse effects
Indian Sub-Continent
Lymphoma
Male
Nephrotic Syndrome - drug therapy
Neutropenia
Neutropenia - chemically induced
Neutropenia - drug therapy
Neutrophils
Rituximab
Sepsis
Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions
United Kingdom
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Summary:A 5-year-old boy presented with neutropenia 9 weeks following the administration of rituximab for management of his steroid-dependent nephrotic syndrome. Extensive investigations failed to identify any underlying cause. In keeping with adult reports, rituximab was thought to be the likely cause for this ‘late-onset’ neutropenia (LOP). He was treated successfully with granulocyte-colony-stimulating factor. Patients treated with rituximab need to be carefully monitored for LOP.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2012-007958