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Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats
Hepatology research has focused on developing traditional therapies as pharmacological medicines to treat liver cirrhosis. Thus, this study evaluated mechanisms of the hepatoprotective activity of Curcuma longa rhizome ethanolic extract (CLRE) on thioacetamide-induced liver cirrhosis in rats. The he...
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| Published in: | BMC complementary and alternative medicine 2013-03, Vol.13 (1), p.56-56, Article 56 |
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| creator | Salama, Suzy M Abdulla, Mahmood Ameen AlRashdi, Ahmed S Ismail, Salmah Alkiyumi, Salim S Golbabapour, Shahram |
| description | Hepatology research has focused on developing traditional therapies as pharmacological medicines to treat liver cirrhosis. Thus, this study evaluated mechanisms of the hepatoprotective activity of Curcuma longa rhizome ethanolic extract (CLRE) on thioacetamide-induced liver cirrhosis in rats.
The hepatoprotective effect of CLRE was measured in a rat model of thioacetamide-induced liver cirrhosis over 8 weeks. Hepatic cytochrome P450 2E1 and serum levels of TGF-β1 and TNF-α were evaluated. Oxidative stress was measured by malondialdehyde, urinary 8-hydroxyguanosine and nitrotyrosine levels. The protective activity of CLRE free-radical scavenging mechanisms were evaluated through antioxidant enzymes. Protein expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins in animal blood sera was studied and confirmed by immunohistochemistry of Bax, Bcl2 proteins and proliferating cell nuclear antigen.
Histopathology, immunohistochemistry and liver biochemistry were significantly lower in the Curcuma longa-treated groups compared with controls. CLRE induced apoptosis, inhibited hepatocytes proliferation but had no effect on hepatic CYP2E1 levels.
The progression of liver cirrhosis could be inhibited by the antioxidant and anti-inflammatory activities of CLRE and the normal status of the liver could be preserved. |
| doi_str_mv | 10.1186/1472-6882-13-56 |
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The hepatoprotective effect of CLRE was measured in a rat model of thioacetamide-induced liver cirrhosis over 8 weeks. Hepatic cytochrome P450 2E1 and serum levels of TGF-β1 and TNF-α were evaluated. Oxidative stress was measured by malondialdehyde, urinary 8-hydroxyguanosine and nitrotyrosine levels. The protective activity of CLRE free-radical scavenging mechanisms were evaluated through antioxidant enzymes. Protein expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins in animal blood sera was studied and confirmed by immunohistochemistry of Bax, Bcl2 proteins and proliferating cell nuclear antigen.
Histopathology, immunohistochemistry and liver biochemistry were significantly lower in the Curcuma longa-treated groups compared with controls. CLRE induced apoptosis, inhibited hepatocytes proliferation but had no effect on hepatic CYP2E1 levels.
The progression of liver cirrhosis could be inhibited by the antioxidant and anti-inflammatory activities of CLRE and the normal status of the liver could be preserved.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/1472-6882-13-56</identifier><identifier>PMID: 23496995</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acids ; Alcohol ; Alcohol, Denatured ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Antigens ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Apoptosis ; Apoptosis - drug effects ; Aquatic plants ; Biological products ; Bone morphogenetic proteins ; Cell Proliferation - drug effects ; Chemical and Drug Induced Liver Injury - metabolism ; Chemical and Drug Induced Liver Injury - pathology ; Chemical and Drug Induced Liver Injury - prevention & control ; Chemical properties ; Curcuma ; Cytochrome P-450 ; Cytochrome P-450 CYP2E1 - metabolism ; Disease Models, Animal ; Drug dosages ; Ethanol ; Health aspects ; Hepatocytes - drug effects ; Histopathology ; Immunohistochemistry ; Laboratory animals ; Liver ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver cirrhosis ; Liver Cirrhosis, Experimental - metabolism ; Liver Cirrhosis, Experimental - pathology ; Liver Cirrhosis, Experimental - prevention & control ; Malondialdehyde - metabolism ; Medical research ; Medicinal plants ; Medicine ; Oxidative stress ; Oxidative Stress - drug effects ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Prevention ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Rats ; Rats, Sprague-Dawley ; Rhizome ; Rodents ; Studies ; Thioacetamide ; Transforming Growth Factor beta1 - metabolism ; Transforming growth factors ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - metabolism ; Turmeric ; Wound healing</subject><ispartof>BMC complementary and alternative medicine, 2013-03, Vol.13 (1), p.56-56, Article 56</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Salama et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright ©2013 Salama et al.; licensee BioMed Central Ltd. 2013 Salama et al.; licensee BioMed Central Ltd.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b644t-f1f372ce0bd4edf9f65830f413c753c915bd4f10f720765c9a84d640043ea3e73</citedby><cites>FETCH-LOGICAL-b644t-f1f372ce0bd4edf9f65830f413c753c915bd4f10f720765c9a84d640043ea3e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605171/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605171/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23496995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salama, Suzy M</creatorcontrib><creatorcontrib>Abdulla, Mahmood Ameen</creatorcontrib><creatorcontrib>AlRashdi, Ahmed S</creatorcontrib><creatorcontrib>Ismail, Salmah</creatorcontrib><creatorcontrib>Alkiyumi, Salim S</creatorcontrib><creatorcontrib>Golbabapour, Shahram</creatorcontrib><title>Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>Hepatology research has focused on developing traditional therapies as pharmacological medicines to treat liver cirrhosis. Thus, this study evaluated mechanisms of the hepatoprotective activity of Curcuma longa rhizome ethanolic extract (CLRE) on thioacetamide-induced liver cirrhosis in rats.
The hepatoprotective effect of CLRE was measured in a rat model of thioacetamide-induced liver cirrhosis over 8 weeks. Hepatic cytochrome P450 2E1 and serum levels of TGF-β1 and TNF-α were evaluated. Oxidative stress was measured by malondialdehyde, urinary 8-hydroxyguanosine and nitrotyrosine levels. The protective activity of CLRE free-radical scavenging mechanisms were evaluated through antioxidant enzymes. Protein expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins in animal blood sera was studied and confirmed by immunohistochemistry of Bax, Bcl2 proteins and proliferating cell nuclear antigen.
Histopathology, immunohistochemistry and liver biochemistry were significantly lower in the Curcuma longa-treated groups compared with controls. CLRE induced apoptosis, inhibited hepatocytes proliferation but had no effect on hepatic CYP2E1 levels.
The progression of liver cirrhosis could be inhibited by the antioxidant and anti-inflammatory activities of CLRE and the normal status of the liver could be preserved.</description><subject>Acids</subject><subject>Alcohol</subject><subject>Alcohol, Denatured</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antigens</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Aquatic plants</subject><subject>Biological products</subject><subject>Bone morphogenetic proteins</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemical and Drug Induced Liver Injury - metabolism</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Chemical and Drug Induced Liver Injury - prevention & control</subject><subject>Chemical properties</subject><subject>Curcuma</subject><subject>Cytochrome P-450</subject><subject>Cytochrome P-450 CYP2E1 - metabolism</subject><subject>Disease Models, Animal</subject><subject>Drug dosages</subject><subject>Ethanol</subject><subject>Health aspects</subject><subject>Hepatocytes - drug effects</subject><subject>Histopathology</subject><subject>Immunohistochemistry</subject><subject>Laboratory animals</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis, Experimental - metabolism</subject><subject>Liver Cirrhosis, Experimental - pathology</subject><subject>Liver Cirrhosis, Experimental - prevention & control</subject><subject>Malondialdehyde - metabolism</subject><subject>Medical research</subject><subject>Medicinal plants</subject><subject>Medicine</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Prevention</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rhizome</subject><subject>Rodents</subject><subject>Studies</subject><subject>Thioacetamide</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><subject>Transforming growth factors</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Turmeric</subject><subject>Wound healing</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1UkFrFDEUHkSxtXr2JgGht2mTSSaZuQh1qVYoeNFzyGZedlJm8tYkU_Tfm2XrsguVHPL43vc-8n15VfWe0SvGOnnNhGpq2XVNzXjdyhfV-QF5eVSfVW9SeqCUqY6J19VZw0Uv-749r8IdbE3GbcQMNvtHIOBcqQg6Ank0ASdvCfzO0ezB1RLtMhsyYdgYgoHk0aOxkM3sByA-DIuFgUxFKhLrYxwx-VRwEk1Ob6tXzkwJ3j3dF9XPL7c_Vnf1_fev31Y39_VaCpFrxxxXjQW6HgQMrney7Th1gnGrWm571paGY9SphirZ2t50YpCCUsHBcFD8ovq0190u6xkGC6EYmPQ2-tnEPxqN16ed4Ee9wUfNJW2ZYkXg815g7fE_Aqcdi7Pe5a13eWvGdSuLyMenV0T8tUDK-gGXGIrxQmCqZ10njlgbM4H2weEu7Nknq29aXgii_FRhXT3DKmeA2VsM4HzBTwYujwZGMFMeE05L9hjSKfF6T7QRU4rgDi4Z1bste8bXh-N0D_x_a8X_Ai1AzeY</recordid><startdate>20130305</startdate><enddate>20130305</enddate><creator>Salama, Suzy M</creator><creator>Abdulla, Mahmood Ameen</creator><creator>AlRashdi, Ahmed S</creator><creator>Ismail, Salmah</creator><creator>Alkiyumi, Salim S</creator><creator>Golbabapour, Shahram</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20130305</creationdate><title>Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats</title><author>Salama, Suzy M ; Abdulla, Mahmood Ameen ; AlRashdi, Ahmed S ; Ismail, Salmah ; Alkiyumi, Salim S ; Golbabapour, Shahram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b644t-f1f372ce0bd4edf9f65830f413c753c915bd4f10f720765c9a84d640043ea3e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acids</topic><topic>Alcohol</topic><topic>Alcohol, Denatured</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - 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Thus, this study evaluated mechanisms of the hepatoprotective activity of Curcuma longa rhizome ethanolic extract (CLRE) on thioacetamide-induced liver cirrhosis in rats.
The hepatoprotective effect of CLRE was measured in a rat model of thioacetamide-induced liver cirrhosis over 8 weeks. Hepatic cytochrome P450 2E1 and serum levels of TGF-β1 and TNF-α were evaluated. Oxidative stress was measured by malondialdehyde, urinary 8-hydroxyguanosine and nitrotyrosine levels. The protective activity of CLRE free-radical scavenging mechanisms were evaluated through antioxidant enzymes. Protein expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins in animal blood sera was studied and confirmed by immunohistochemistry of Bax, Bcl2 proteins and proliferating cell nuclear antigen.
Histopathology, immunohistochemistry and liver biochemistry were significantly lower in the Curcuma longa-treated groups compared with controls. CLRE induced apoptosis, inhibited hepatocytes proliferation but had no effect on hepatic CYP2E1 levels.
The progression of liver cirrhosis could be inhibited by the antioxidant and anti-inflammatory activities of CLRE and the normal status of the liver could be preserved.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23496995</pmid><doi>10.1186/1472-6882-13-56</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1472-6882 |
| ispartof | BMC complementary and alternative medicine, 2013-03, Vol.13 (1), p.56-56, Article 56 |
| issn | 1472-6882 1472-6882 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3605171 |
| source | PubMed Central |
| subjects | Acids Alcohol Alcohol, Denatured Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antigens Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis Apoptosis - drug effects Aquatic plants Biological products Bone morphogenetic proteins Cell Proliferation - drug effects Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Chemical properties Curcuma Cytochrome P-450 Cytochrome P-450 CYP2E1 - metabolism Disease Models, Animal Drug dosages Ethanol Health aspects Hepatocytes - drug effects Histopathology Immunohistochemistry Laboratory animals Liver Liver - drug effects Liver - metabolism Liver - pathology Liver cirrhosis Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - pathology Liver Cirrhosis, Experimental - prevention & control Malondialdehyde - metabolism Medical research Medicinal plants Medicine Oxidative stress Oxidative Stress - drug effects Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Prevention Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Sprague-Dawley Rhizome Rodents Studies Thioacetamide Transforming Growth Factor beta1 - metabolism Transforming growth factors Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Turmeric Wound healing |
| title | Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats |
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