Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence

Abstract Purpose To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents. Methods Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpati...

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Bibliographic Details
Published in:Journal of adolescent health 2013-04, Vol.52 (4), p.502-505
Main Authors: Heinzerling, Keith G., M.D, Gadzhyan, Janette, van Oudheusden, Henry, M.S.W, Rodriguez, Felipe, C.C.S, McCracken, James, M.D, Shoptaw, Steven, Ph.D
Format: Article
Language:English
Subjects:
Addictive behaviors
Adolescent
Adolescents
Adult and adolescent clinical studies
Ambulatory Care
Amphetamine-Related Disorders - rehabilitation
Antidepressive Agents, Second-Generation - adverse effects
Antidepressive Agents, Second-Generation - therapeutic use
Biological and medical sciences
Bupropion
Bupropion - adverse effects
Bupropion - therapeutic use
Clinical outcomes
Clinical trial
Delayed-Action Preparations
Desintoxication. Drug withdrawal
Drug addiction
Feasibility
Female
Humans
Los Angeles
Male
Medical sciences
Methamphetamine
Pediatrics
Pilot Projects
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Secondary Prevention
Sex Factors
Substance abuse
Substance Abuse Detection - statistics & numerical data
Substance Abuse, Intravenous - rehabilitation
Treatments
Young Adult
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Summary:Abstract Purpose To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents. Methods Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling. Results Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo ( p  = .043) and males ( p  = .005) respectively. Conclusions Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.
ISSN:1054-139X
1879-1972
DOI:10.1016/j.jadohealth.2012.10.275