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Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence
Abstract Purpose To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents. Methods Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpati...
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| Published in: | Journal of adolescent health 2013-04, Vol.52 (4), p.502-505 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c663t-812f029e93f9dea409300ba1587340167852b19b55b7526a45caa4b2a1846fe43 |
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| cites | cdi_FETCH-LOGICAL-c663t-812f029e93f9dea409300ba1587340167852b19b55b7526a45caa4b2a1846fe43 |
| container_end_page | 505 |
| container_issue | 4 |
| container_start_page | 502 |
| container_title | Journal of adolescent health |
| container_volume | 52 |
| creator | Heinzerling, Keith G., M.D Gadzhyan, Janette van Oudheusden, Henry, M.S.W Rodriguez, Felipe, C.C.S McCracken, James, M.D Shoptaw, Steven, Ph.D |
| description | Abstract Purpose To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents. Methods Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling. Results Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo ( p = .043) and males ( p = .005) respectively. Conclusions Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes. |
| doi_str_mv | 10.1016/j.jadohealth.2012.10.275 |
| format | article |
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Methods Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling. Results Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo ( p = .043) and males ( p = .005) respectively. Conclusions Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.</description><identifier>ISSN: 1054-139X</identifier><identifier>EISSN: 1879-1972</identifier><identifier>DOI: 10.1016/j.jadohealth.2012.10.275</identifier><identifier>PMID: 23333007</identifier><identifier>CODEN: JAHCD9</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Addictive behaviors ; Adolescent ; Adolescents ; Adult and adolescent clinical studies ; Ambulatory Care ; Amphetamine-Related Disorders - rehabilitation ; Antidepressive Agents, Second-Generation - adverse effects ; Antidepressive Agents, Second-Generation - therapeutic use ; Biological and medical sciences ; Bupropion ; Bupropion - adverse effects ; Bupropion - therapeutic use ; Clinical outcomes ; Clinical trial ; Delayed-Action Preparations ; Desintoxication. Drug withdrawal ; Drug addiction ; Feasibility ; Female ; Humans ; Los Angeles ; Male ; Medical sciences ; Methamphetamine ; Pediatrics ; Pilot Projects ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Secondary Prevention ; Sex Factors ; Substance abuse ; Substance Abuse Detection - statistics & numerical data ; Substance Abuse, Intravenous - rehabilitation ; Treatments ; Young Adult</subject><ispartof>Journal of adolescent health, 2013-04, Vol.52 (4), p.502-505</ispartof><rights>Society for Adolescent Health and Medicine</rights><rights>2013 Society for Adolescent Health and Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.</rights><rights>2012 Society for Adolescent Medicine. Published by Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c663t-812f029e93f9dea409300ba1587340167852b19b55b7526a45caa4b2a1846fe43</citedby><cites>FETCH-LOGICAL-c663t-812f029e93f9dea409300ba1587340167852b19b55b7526a45caa4b2a1846fe43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925,31000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27212099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23333007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heinzerling, Keith G., M.D</creatorcontrib><creatorcontrib>Gadzhyan, Janette</creatorcontrib><creatorcontrib>van Oudheusden, Henry, M.S.W</creatorcontrib><creatorcontrib>Rodriguez, Felipe, C.C.S</creatorcontrib><creatorcontrib>McCracken, James, M.D</creatorcontrib><creatorcontrib>Shoptaw, Steven, Ph.D</creatorcontrib><title>Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence</title><title>Journal of adolescent health</title><addtitle>J Adolesc Health</addtitle><description>Abstract Purpose To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents. Methods Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling. Results Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo ( p = .043) and males ( p = .005) respectively. Conclusions Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.</description><subject>Addictive behaviors</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult and adolescent clinical studies</subject><subject>Ambulatory Care</subject><subject>Amphetamine-Related Disorders - rehabilitation</subject><subject>Antidepressive Agents, Second-Generation - adverse effects</subject><subject>Antidepressive Agents, Second-Generation - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bupropion</subject><subject>Bupropion - adverse effects</subject><subject>Bupropion - therapeutic use</subject><subject>Clinical outcomes</subject><subject>Clinical trial</subject><subject>Delayed-Action Preparations</subject><subject>Desintoxication. Drug withdrawal</subject><subject>Drug addiction</subject><subject>Feasibility</subject><subject>Female</subject><subject>Humans</subject><subject>Los Angeles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methamphetamine</subject><subject>Pediatrics</subject><subject>Pilot Projects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Secondary Prevention</subject><subject>Sex Factors</subject><subject>Substance abuse</subject><subject>Substance Abuse Detection - statistics & numerical data</subject><subject>Substance Abuse, Intravenous - rehabilitation</subject><subject>Treatments</subject><subject>Young Adult</subject><issn>1054-139X</issn><issn>1879-1972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqNUk1v1TAQjBCIlsJfQLkgccmr7Xw4vlR6LS2tVASiReJmbZwNcXDsYCeVyq_H0Xu0wAlfbO3Ozo53NklSSjaU0Op42AzQuh7BzP2GEcpieMN4-SQ5pDUXGRWcPY1vUhYZzcXXg-RFCAOJpRUlz5MDlsdDCD9Mbj5p4-b0M9jWjfontumt12BS16Wny-TdpJ1NO-fTbesMBoV2Tj_g3MM49TjDqC2m22YJePwOJ7QtWoUvk2cdmICv9vdR8uXi_PbsMrv--P7qbHudqarK56ymrCNMoMg70SIURERJDdCy5nkRpfK6ZA0VTVk2vGQVFKUCKBoGtC6qDov8KDnZ8U5LM2K7avNg5OT1CP5eOtDy74zVvfzm7mRekbomZSR4uyfw7seCYZajjl80Biy6JUiaVwVfR7ZC6x1UeReCx-6hDSVy9UQO8tETuXqyZqInsfT1nzIfCn-bEAFv9gAICkznwSodHnGcUUaEiLjTHQ7jUO80ehmUXgfeao9qlq3T_6Pm5B8SZbTVse93vMcwuMXbaJqkMjBJ5M26Q-sKRQmEU1bkvwBKKsTx</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Heinzerling, Keith G., M.D</creator><creator>Gadzhyan, Janette</creator><creator>van Oudheusden, Henry, M.S.W</creator><creator>Rodriguez, Felipe, C.C.S</creator><creator>McCracken, James, M.D</creator><creator>Shoptaw, Steven, Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>5PM</scope></search><sort><creationdate>20130401</creationdate><title>Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence</title><author>Heinzerling, Keith G., M.D ; Gadzhyan, Janette ; van Oudheusden, Henry, M.S.W ; Rodriguez, Felipe, C.C.S ; McCracken, James, M.D ; Shoptaw, Steven, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c663t-812f029e93f9dea409300ba1587340167852b19b55b7526a45caa4b2a1846fe43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Addictive behaviors</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult and adolescent clinical studies</topic><topic>Ambulatory Care</topic><topic>Amphetamine-Related Disorders - rehabilitation</topic><topic>Antidepressive Agents, Second-Generation - adverse effects</topic><topic>Antidepressive Agents, Second-Generation - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bupropion</topic><topic>Bupropion - adverse effects</topic><topic>Bupropion - therapeutic use</topic><topic>Clinical outcomes</topic><topic>Clinical trial</topic><topic>Delayed-Action Preparations</topic><topic>Desintoxication. Drug withdrawal</topic><topic>Drug addiction</topic><topic>Feasibility</topic><topic>Female</topic><topic>Humans</topic><topic>Los Angeles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methamphetamine</topic><topic>Pediatrics</topic><topic>Pilot Projects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Secondary Prevention</topic><topic>Sex Factors</topic><topic>Substance abuse</topic><topic>Substance Abuse Detection - statistics & numerical data</topic><topic>Substance Abuse, Intravenous - rehabilitation</topic><topic>Treatments</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heinzerling, Keith G., M.D</creatorcontrib><creatorcontrib>Gadzhyan, Janette</creatorcontrib><creatorcontrib>van Oudheusden, Henry, M.S.W</creatorcontrib><creatorcontrib>Rodriguez, Felipe, C.C.S</creatorcontrib><creatorcontrib>McCracken, James, M.D</creatorcontrib><creatorcontrib>Shoptaw, Steven, Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of adolescent health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heinzerling, Keith G., M.D</au><au>Gadzhyan, Janette</au><au>van Oudheusden, Henry, M.S.W</au><au>Rodriguez, Felipe, C.C.S</au><au>McCracken, James, M.D</au><au>Shoptaw, Steven, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence</atitle><jtitle>Journal of adolescent health</jtitle><addtitle>J Adolesc Health</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>52</volume><issue>4</issue><spage>502</spage><epage>505</epage><pages>502-505</pages><issn>1054-139X</issn><eissn>1879-1972</eissn><coden>JAHCD9</coden><abstract>Abstract Purpose To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents. Methods Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling. Results Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo ( p = .043) and males ( p = .005) respectively. Conclusions Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23333007</pmid><doi>10.1016/j.jadohealth.2012.10.275</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1054-139X |
| ispartof | Journal of adolescent health, 2013-04, Vol.52 (4), p.502-505 |
| issn | 1054-139X 1879-1972 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3608805 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Elsevier |
| subjects | Addictive behaviors Adolescent Adolescents Adult and adolescent clinical studies Ambulatory Care Amphetamine-Related Disorders - rehabilitation Antidepressive Agents, Second-Generation - adverse effects Antidepressive Agents, Second-Generation - therapeutic use Biological and medical sciences Bupropion Bupropion - adverse effects Bupropion - therapeutic use Clinical outcomes Clinical trial Delayed-Action Preparations Desintoxication. Drug withdrawal Drug addiction Feasibility Female Humans Los Angeles Male Medical sciences Methamphetamine Pediatrics Pilot Projects Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Secondary Prevention Sex Factors Substance abuse Substance Abuse Detection - statistics & numerical data Substance Abuse, Intravenous - rehabilitation Treatments Young Adult |
| title | Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence |
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