Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer

Previous studies report conflicting data on outcomes of pregnancy-associated breast cancer (PABC). Our aim was to examine the effect of a postpartum diagnosis on maternal prognosis in a young women’s breast cancer cohort. We conducted a retrospective cohort study of women age ≤45 years, diagnosed wi...

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Bibliographic Details
Published in:Breast cancer research and treatment 2013-04, Vol.138 (2), p.549-559
Main Authors: Callihan, Eryn B., Gao, Dexiang, Jindal, Sonali, Lyons, Traci R., Manthey, Elizabeth, Edgerton, Susan, Urquhart, Alexander, Schedin, Pepper, Borges, Virginia F.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Breast cancer
Breast Neoplasms - classification
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer research
Cancer therapies
Carcinoma, Ductal, Breast - classification
Carcinoma, Ductal, Breast - mortality
Carcinoma, Ductal, Breast - secondary
Epidemiology
Female
Gynecology. Andrology. Obstetrics
Health aspects
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis
Mammary gland diseases
Medical sciences
Medicine
Medicine & Public Health
Metastasis
Mortality
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Multivariate Analysis
Oncology
Postpartum Period
Pregnancy
Pregnancy Complications, Neoplastic - classification
Pregnancy Complications, Neoplastic - mortality
Pregnancy Complications, Neoplastic - pathology
Pregnant women
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk
Risk factors
Tumors
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Summary:Previous studies report conflicting data on outcomes of pregnancy-associated breast cancer (PABC). Our aim was to examine the effect of a postpartum diagnosis on maternal prognosis in a young women’s breast cancer cohort. We conducted a retrospective cohort study of women age ≤45 years, diagnosed with breast cancer ( n  = 619) during 1981–2011 at the University of Colorado Hospital and The Shaw Cancer Center in Edwards, CO. Breast cancer cases were grouped according to time between giving birth and diagnosis: nulliparous ( n  = 125), pregnant ( n  = 24), 5—
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-013-2437-x