Protective efficacy of orally administered, heat-killed Lactobacillus pentosus b240 against influenza A virus

Influenza A(H1N1)pdm virus caused the first human pandemic of the 21st century. Although various probiotic Lactobacillus species have been shown to have anti-microbial effects against pneumonia-inducing pathogens, the prophylactic efficacy and mechanisms behind their protection remain largely unknow...

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Bibliographic Details
Published in:Scientific reports 2013-03, Vol.3 (1), p.1563-1563, Article 1563
Main Authors: Kiso, Maki, Takano, Ryo, Sakabe, Saori, Katsura, Hiroaki, Shinya, Kyoko, Uraki, Ryuta, Watanabe, Shinji, Saito, Hiroshi, Toba, Masamichi, Kohda, Noriyuki, Kawaoka, Yoshihiro
Format: Article
Language:English
Subjects:
631/250/2499
631/250/254
631/326/596/1578
631/326/596/2553
Administration, Oral
Animals
Antiviral Agents - administration & dosage
Antiviral Agents - therapeutic use
Cell Line
Chemokines - metabolism
Cytokines - metabolism
Dogs
Early Growth Response Protein 1 - biosynthesis
Female
Gene expression
Histopathology
Humanities and Social Sciences
Immunity, Innate - drug effects
Immunity, Innate - immunology
Influenza
Influenza A
Influenza A Virus, H1N1 Subtype
Lactobacillus
Lung - virology
Madin Darby Canine Kidney Cells
Mice
Mice, Inbred BALB C
multidisciplinary
Oral administration
Orthomyxoviridae Infections - therapy
Orthomyxoviridae Infections - virology
Pandemics
Probiotics
Probiotics - administration & dosage
Probiotics - therapeutic use
Rodents
Science
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Summary:Influenza A(H1N1)pdm virus caused the first human pandemic of the 21st century. Although various probiotic Lactobacillus species have been shown to have anti-microbial effects against pneumonia-inducing pathogens, the prophylactic efficacy and mechanisms behind their protection remain largely unknown. Here, we evaluated the prophylactic efficacy of heat-killed Lactobacillus pentosus b240 against lethal influenza A(H1N1)pdm virus infection in a mouse model. To further define the protective responses induced by b240, we performed virologic, histopathologic and transcriptomic analyses on the mouse lungs. Although we did not observe an appreciable effect of b240 on virus growth, cytokine production, or histopathology, gene expressional analysis revealed that oral administration of b240 differentially regulates antiviral gene expression in mouse lungs. Our results unveil the possible mechanisms behind the protection mediated by b240 against influenza virus infection and provide new insights into probiotic therapy.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep01563