Energy expenditure in obese children with pseudohypoparathyroidism type 1a

Context: Patients with pseudohypoparathyroidism type 1a (PHP-1a) develop early-onset obesity. The abnormality in energy expenditure and/or energy intake responsible for this weight gain is unknown. Objective: The aim of this study was to evaluate energy expenditure in children with PHP-1a compared w...

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Bibliographic Details
Published in:International Journal of Obesity 2013-08, Vol.37 (8), p.1147-1153
Main Authors: Shoemaker, A H, Lomenick, J P, Saville, B R, Wang, W, Buchowski, M S, Cone, R D
Format: Article
Language:English
Subjects:
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Absorptiometry, Photon
Adolescent
Age of Onset
Basal Metabolism
Bioenergetics
Biological and medical sciences
Blood Glucose - metabolism
Body Composition
Body mass index
Calorimetry
Calorimetry, Indirect
Child
Complications and side effects
Demographic aspects
Disease Susceptibility
Endocrinology
Endocrinopathies
Energy
Energy metabolism
Energy Metabolism - genetics
Epidemiology
Female
Females
General aspects
Genotype & phenotype
Glycated Hemoglobin A - metabolism
Health Promotion and Disease Prevention
Humans
Hypothyroidism
Insulin
Insulin - blood
Insulin resistance
Internal Medicine
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Mutation
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Obesity
Obesity in children
original-article
Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)
Pediatric Obesity - epidemiology
Pediatric Obesity - genetics
Pediatric Obesity - metabolism
Pediatrics
Phenotype
Polymorphism, Single Nucleotide
Postprandial Period
Pseudohypoparathyroidism
Pseudohypoparathyroidism - epidemiology
Pseudohypoparathyroidism - genetics
Pseudohypoparathyroidism - metabolism
Public Health
Rest
Risk factors
Standard scores
Thermogenesis
United States - epidemiology
Weight control
Weight Gain
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Summary:Context: Patients with pseudohypoparathyroidism type 1a (PHP-1a) develop early-onset obesity. The abnormality in energy expenditure and/or energy intake responsible for this weight gain is unknown. Objective: The aim of this study was to evaluate energy expenditure in children with PHP-1a compared with obese controls. Patients: We studied 6 obese females with PHP-1a and 17 obese female controls. Patients were recruited from a single academic center. Measurements: Resting energy expenditure (REE) and thermogenic effect of a high fat meal were measured using whole room indirect calorimetry. Body composition was assessed using whole body dual energy x-ray absorptiometry. Fasting glucose, insulin, and hemoglobin A1C were measured. Results: Children with PHP-1a had decreased REE compared with obese controls ( P
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2012.200