Pregnancy-induced changes in immune protection of the genital tract: defining normal

Objective Both the state of pregnancy as well as disruption of vaginal flora and immune mediators may increase the risk of human immunodeficiency virus-1 acquisition. The objective of this study was to define immune changes in lower genital and systemic immunity associated with normal pregnancy. Stu...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2013-04, Vol.208 (4), p.321.e1-321.e9
Main Authors: Anderson, Brenna L., MD, MSc, Mendez-Figueroa, Hector, MD, Dahlke, Joshua D., MD, Raker, Christina, ScM, ScD, Hillier, Sharon L., PhD, Cu-Uvin, Susan, MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
C-Reactive Protein - analysis
Cervix Uteri - immunology
Cervix Uteri - microbiology
cytokines
Female
genital flora
Humans
inflammation
Interleukin-1beta - analysis
Menstrual Cycle - blood
Menstrual Cycle - immunology
Obstetrics and Gynecology
pregnancy
Pregnancy - immunology
Prospective Studies
Vagina - immunology
Vagina - microbiology
vaginal immunity
Young Adult
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Summary:Objective Both the state of pregnancy as well as disruption of vaginal flora and immune mediators may increase the risk of human immunodeficiency virus-1 acquisition. The objective of this study was to define immune changes in lower genital and systemic immunity associated with normal pregnancy. Study Design This prospective cohort enrolled low-risk pregnant and nonpregnant women ages 18-35 years. Pregnant women at 60% pregnant participants. Conclusion The proinflammatory cytokine, interleukin-1β, as well as the systemic marker of inflammation, C-reactive protein, are increased during pregnancy. The impact of these proinflammatory changes during pregnancy deserves further study.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2013.01.014