A mechanism for upper airway stability during slow wave sleep

• Published in: Sleep (New York, N.Y.) N.Y.), 2013-04, Vol.36 (4), p.555-563
• Main Authors: McSharry, David G, Saboisky, Julian P, Deyoung, Pam, Matteis, Paul, Jordan, Amy S, Trinder, John, Smales, Erik, Hess, Lauren, Guo, Mengshuang, Malhotra, Atul
• Format: Article
• Language: English
• Subjects: A Mechanism for Upper Airway Stability during Slow Wave Sleep; Adult; Electrodes, Implanted; Electroencephalography - methods; Electromyography - methods; Female; Humans; Male; Motor Neurons - physiology; Muscle, Skeletal - physiology; Polysomnography - methods; Recruitment, Neurophysiological - physiology; Respiratory Mechanics - physiology; Respiratory Muscles - physiology; Sleep - physiology; Tongue - physiology
• ISSN: 0161-8105; 1550-9109
• DOI: 10.5665/sleep.2544

The severity of obstructive sleep apnea is diminished (sometimes markedly) during slow wave sleep (SWS). We sought to understand why SWS stabilizes the upper airway. Increased single motor unit (SMU) activity of the major upper airway dilating muscle (genioglossus) should improve upper airway stability. Therefore, we hypothesized that genioglossus SMUs would increase their activity during SWS in comparison with Stage N2 sleep. The activity of genioglossus SMUs was studied on both sides of the transition between Stage N2 sleep and SWS. Sleep laboratory. Twenty-nine subjects (age 38 ± 13 yr, 17 males) were studied. SWS. Subjects slept overnight with fine-wire electrodes in their genioglossus muscles and with full polysomnographic and end tidal carbon dioxide monitors. Fifteen inspiratory phasic (IP) and 11 inspiratory tonic (IT) units were identified from seven subjects and these units exhibited significantly increased inspiratory discharge frequencies during SWS compared with Stage N2 sleep. The peak discharge frequency of the inspiratory units (IP and IT) was 22.7 ± 4.1 Hz in SWS versus 20.3 ± 4.5 Hz in Stage N2 (P < 0.001). The IP units also fired for a longer duration (expressed as a percentage of inspiratory time) during SWS (104.6 ± 39.5 %TI) versus Stage N2 sleep (82.6 ± 39.5 %TI, P < 0.001). The IT units fired faster during expiration in SWS (14.2 ± 1.8 Hz) versus Stage N2 sleep (12.6 ± 3.1 Hz, P = 0.035). There was minimal recruitment or derecruitment of units between SWS and Stage N2 sleep. Increased genioglossus SMU activity likely makes the airway more stable and resistant to collapse throughout the respiratory cycle during SWS.