Emu Oil Reduces Small Intestinal Inflammation in the Absence of Clinical Improvement in a Rat Model of Indomethacin-Induced Enteropathy

Nonsteroidal-anti-inflammatory-drug (NSAID) enteropathy is characterized by small intestinal damage and ulceration. Emu Oil (EO) has previously been reported to reduce intestinal inflammation. Aim. We investigated EO for its potential to attenuate NSAID-enteropathy in rats. Methods. Male Sprague Daw...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-10
Main Authors: Abimosleh, Suzanne M., Tran, Cuong D., Howarth, Gordon S.
Format: Article
Language:English
Subjects:
Analgesics
Colon
Cytokines
Duodenum
Fatty acids
Fish oils
Ileum
Immunology
Indomethacin
Inflammation
Inflammatory bowel disease
Intestine
Jejunum
Liver
Nonsteroidal anti-inflammatory drugs
Oils & fats
Olive oil
Oxidative stress
Pathogenesis
Permeability
Peroxidase
Physiology
Rats
Rodents
Spleen
Sucrose
Sugar
Thymus
Tumor necrosis factor-TNF
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Summary:Nonsteroidal-anti-inflammatory-drug (NSAID) enteropathy is characterized by small intestinal damage and ulceration. Emu Oil (EO) has previously been reported to reduce intestinal inflammation. Aim. We investigated EO for its potential to attenuate NSAID-enteropathy in rats. Methods. Male Sprague Dawley rats (n=10/group) were gavaged with Water, Olive Oil (OO), or EO (0.5 mL; days 0–12) and with 0.5 mL Water or the NSAID, Indomethacin (8 mg/kg; days 5–12) daily. Disease activity index (DAI), 13C-sucrose breath test (SBT), organ weights, intestinal damage severity (IDS), and myeloperoxidase (MPO) activity were assessed. P
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/429706