Chromatin organization and transcriptional regulation

Cell type specific transcriptional regulation must be adhered to in order to maintain cell identity throughout the lifetime of an organism, yet it must be flexible enough to allow for responses to endogenous and exogenous stimuli. This regulation is mediated not only by molecular factors (e.g. cell...

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Bibliographic Details
Published in:Current opinion in genetics & development 2013-04, Vol.23 (2), p.89-95
Main Authors: Hübner, Michael R, Eckersley-Maslin, Mélanie A, Spector, David L
Format: Article
Language:English
Subjects:
Cell Nucleus - metabolism
Chromatin - genetics
Gene Expression Regulation
Genome
Histones - genetics
Histones - metabolism
Humans
Medical Education
Nuclear Lamina - genetics
Transcription, Genetic
Transcriptional Activation - genetics
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Summary:Cell type specific transcriptional regulation must be adhered to in order to maintain cell identity throughout the lifetime of an organism, yet it must be flexible enough to allow for responses to endogenous and exogenous stimuli. This regulation is mediated not only by molecular factors (e.g. cell type specific transcription factors, histone and DNA modifications), but also on the level of chromatin and genome organization. In this review we focus on recent findings that have contributed to our understanding of higher order chromatin structure and genome organization within the nucleus. We highlight new findings on the dynamic positioning of genes relative to each other, as well as to their chromosome territory and the nuclear lamina, and how the position of genes correlates with their transcriptional activity.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2012.11.006