The Hypertension in the Very Elderly Trial – latest data

Early trials in the field of hypertension focused on adults in their fifties and sixties. However, with the passage of time, a progressive effort has been made to expand the evidence base for treatment in older adults. 2008 saw publication of data from the Hypertension in the Very Elderly Trial whic...

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Bibliographic Details
Published in:British journal of clinical pharmacology 2013-04, Vol.75 (4), p.951-954
Main Authors: Mukhtar, Omar, Jackson, Stephen H. D.
Format: Article
Language:English
Subjects:
Aged, 80 and over
Antihypertensive Agents - therapeutic use
Cognition Disorders - complications
Cognition Disorders - drug therapy
Delayed-Action Preparations - therapeutic use
Dementia - complications
Dementia - drug therapy
Double-Blind Method
Drug Therapy, Combination
elderly
Fractures, Bone - complications
Fractures, Bone - drug therapy
Humans
hypertension
Hypertension - complications
Hypertension - drug therapy
HYVET
Indapamide - administration & dosage
Indapamide - therapeutic use
Multicenter Studies as Topic
older adults
Perindopril - administration & dosage
Perindopril - therapeutic use
Randomized Controlled Trials as Topic
Reviews
treatment
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Summary:Early trials in the field of hypertension focused on adults in their fifties and sixties. However, with the passage of time, a progressive effort has been made to expand the evidence base for treatment in older adults. 2008 saw publication of data from the Hypertension in the Very Elderly Trial which demonstrated significant mortality and morbidity benefits from antihypertensive therapy in octogenarians. More recently, additional data from this cohort has been published suggesting that appropriate anti‐hypertensive therapy may lead to a reduction in incident cognitive impairment and fractures, whilst a 1 year open label extension of the main study confirmed many of the original trial findings. This review provides an overview of the Hypertension in the Very Elderly Trial whilst also discursively evaluating the latest data.
ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.2012.04427.x