A Single Nucleotide Polymorphism in the Phospholipase D1 Gene is Associated with Risk of Non-Small Cell Lung Cancer

Phospholipase D (PLD) has an important role in various biological functions including vesicular transport, endocytosis, exocytosis, cell migration, and mitosis. These cellular biological processes are deregulated in the development of various human tumors. In order to explore the relationship betwee...

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Bibliographic Details
Published in:International journal of biomedical science 2012-06, Vol.8 (2), p.121-128
Main Authors: Ahn, Myung-Ju, Park, Shin-Young, Kim, Won Kyu, Cho, Ju Hwan, Chang, Brian Junho, Kim, Dong Jo, Ahn, Jin Seok, Park, Keunchil, Han, Joong-Soo
Format: Article
Language:English
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Summary:Phospholipase D (PLD) has an important role in various biological functions including vesicular transport, endocytosis, exocytosis, cell migration, and mitosis. These cellular biological processes are deregulated in the development of various human tumors. In order to explore the relationship between the PLD1 gene and risk of non-small cell lung cancer (NSCLC), single nucleotide polymorphisms (SNP) in the PLD1 exon region were surveyed in 211 NSCLC patients and 205 normal controls. In this study, we identified six SNPs at exon 23 in the PLD1 gene. Among the six SNPs, the most notable was a heterozygous A to C transition at nucleotide 2698 (A2698C, p
ISSN:1550-9702
1555-2810