Methane and Hydrogen Positivity on Breath Test Is Associated With Greater Body Mass Index and Body Fat

Context: Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects. Objective: The objective of the study...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2013-04, Vol.98 (4), p.E698-E702
Main Authors: Mathur, R, Amichai, M, Chua, K. S, Mirocha, J, Barlow, G. M, Pimentel, M
Format: Article
Language:English
Subjects:
Adipose Tissue - anatomy & histology
Adiposity - physiology
Adult
Aged
Animal models
Body Composition - physiology
Body fat
Body Mass Index
Breath Tests
Cohort Studies
Colonization
Fat metabolism
Female
Gastrointestinal tract
Humans
Hydrogen
Hydrogen - analysis
Hydrogen - metabolism
JCEM Online: Brief Reports
Lactulose
Male
Methane
Methane - analysis
Methane - metabolism
Methanogenic archaea
Methanogenic bacteria
Middle Aged
Mouth Breathing - metabolism
Nutrient availability
Obesity - metabolism
Population studies
Weight
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Summary:Context: Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects. Objective: The objective of the study was to characterize the relationship between methane and hydrogen on breath test (as a surrogate for colonization with the hydrogen requiring methanogen, Methanobrevibacter smithii), body weight, and percent body fat in a general population cohort. Design and Subjects: This was a prospective study (n = 792) of consecutive subjects presenting for breath testing. Setting: The study was conducted at a tertiary care center. Outcome Measurements: BMI and percent body fat were measured. Results: Subjects were classified into 4 groups based on breath testing: normal (N) (methane
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2012-3144