Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration

Highlights ► Effects of estrogens and androgens in neuroinflammation and neurodegeneration. ► Effects of estrogens on receptors in the immune and central nervous systems. ► Mechanisms of androgens in the immune and central nervous systems.

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Bibliographic Details
Published in:Frontiers in neuroendocrinology 2012-01, Vol.33 (1), p.105-115
Main Authors: Spence, Rory D, Voskuhl, Rhonda R
Format: Article
Language:English
Subjects:
5αDHT
Animals
Central Nervous System Diseases - drug therapy
Dihydrotestosterone - therapeutic use
Disease Models, Animal
EAE
Encephalomyelitis, Autoimmune, Experimental - drug therapy
Encephalomyelitis, Autoimmune, Experimental - immunology
Endocrinology & Metabolism
ERα
ERβ
Estradiol
Estradiol - therapeutic use
Estriol
Estriol - therapeutic use
Estrogen Receptor alpha - physiology
Estrogen Receptor beta - physiology
Estrogens - therapeutic use
Female
Humans
Inflammation - drug therapy
Male
Mice
Multiple Sclerosis - drug therapy
Multiple Sclerosis - immunology
Neuroprotection
Neuroprotective Agents - therapeutic use
Pregnancy
Selective Estrogen Receptor Modulators - therapeutic use
Species Specificity
Testosterone
Testosterone - therapeutic use
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Description
Summary:Highlights ► Effects of estrogens and androgens in neuroinflammation and neurodegeneration. ► Effects of estrogens on receptors in the immune and central nervous systems. ► Mechanisms of androgens in the immune and central nervous systems.
ISSN:0091-3022
1095-6808
DOI:10.1016/j.yfrne.2011.12.001