Developments in the Identification of Glycan Biomarkers for the Detection of Cancer

Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This...

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Bibliographic Details
Published in:Molecular & cellular proteomics 2013-04, Vol.12 (4), p.846-855
Main Authors: Ruhaak, L. Renee, Miyamoto, Suzanne, Lebrilla, Carlito B.
Format: Article
Language:English
Subjects:
Animals
Antigens, Tumor-Associated, Carbohydrate - blood
Antigens, Tumor-Associated, Carbohydrate - chemistry
Antigens, Tumor-Associated, Carbohydrate - isolation & purification
Carbohydrate Conformation
Carbohydrate Sequence
Glycoproteins - blood
Glycoproteins - chemistry
Glycoproteins - isolation & purification
Glycosylation
Humans
Mass Spectrometry
Molecular Sequence Data
Neoplasms - blood
Neoplasms - diagnosis
Polysaccharides - blood
Polysaccharides - chemistry
Polysaccharides - isolation & purification
Prognosis
Protein Processing, Post-Translational
Proteome - chemistry
Proteome - isolation & purification
Proteome - metabolism
Review
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Summary:Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This review is an overview of the developments made in the search for glycan-based cancer biomarkers and the technologies currently in use. It is anticipated that the progressing instrumental and bioinformatics developments will allow the identification of relevant glycan biomarkers for the diagnosis, early detection, and monitoring of cancer treatment with sufficient sensitivity and specificity for clinical use.
ISSN:1535-9476
1535-9484
DOI:10.1074/mcp.R112.026799