Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI

We report in this communication a simple, facile surface modification strategy to transfer hydrophobic manganese oxide nanoparticles (MONPs) into water by using polyaspartic acid (PASP). We systematically investigated the effect of the size of PASP-MONPs on MRI of normal liver and found that the par...

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Bibliographic Details
Published in:Nanoscale 2011-01, Vol.3 (12), p.4943-4945
Main Authors: Xing, Ruijun, Zhang, Fan, Xie, Jin, Aronova, Maria, Zhang, Guofeng, Guo, Ning, Huang, Xinglu, Sun, Xiaolian, Liu, Gang, Bryant, L Henry, Bhirde, Ashwinkumar, Liang, Amy, Hou, Yanglong, Leapman, Richard D, Sun, Shouheng, Chen, Xiaoyuan
Format: Article
Language:English
Subjects:
Animals
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
Contrast Media - chemistry
Contrast Media - pharmacology
Liver
Liver - diagnostic imaging
Magnesium Oxide - chemistry
Magnesium Oxide - pharmacology
Magnetic Resonance Imaging - methods
Manganese oxides
Mice
Nanocomposites
Nanomaterials
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Particle Size
Peptides - chemistry
Peptides - pharmacology
Radiography
Strategy
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Summary:We report in this communication a simple, facile surface modification strategy to transfer hydrophobic manganese oxide nanoparticles (MONPs) into water by using polyaspartic acid (PASP). We systematically investigated the effect of the size of PASP-MONPs on MRI of normal liver and found that the particles with a core size of 10 nm exhibited greater enhancement than those with larger core sizes.
ISSN:2040-3364
2040-3372
DOI:10.1039/c1nr11242b