Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins

Background: Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity. Methods: We investigated whether fecal microbial d...

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Bibliographic Details
Published in:British journal of cancer 2013-03, Vol.108 (5), p.1163-1167
Main Authors: Cozen, W, Yu, G, Gail, M H, Ridaura, V K, Nathwani, B N, Hwang, A E, Hamilton, A S, Mack, T M, Gordon, J I, Goedert, J J
Format: Article
Language:English
Subjects:
692/698/2741/2135
692/699/67/1990/291/1556
692/700/478/174
Adolescent
Adult
Bacteria - genetics
Bacteria - isolation & purification
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Drug Resistance
Epidemiology
Feces
Feces - microbiology
Hematologic and hematopoietic diseases
Hodgkin Disease - microbiology
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma
Male
Medical sciences
Medicine
Metagenome
Microbiota
Molecular Medicine
Oncology
Short Communication
Survivors
Tumors
Twin studies
Twins
Young Adult
Young adults
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Summary:Background: Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity. Methods: We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their unaffected co-twin controls. Pyrosequencing of fecal bacterial 16S rRNA amplicons yielded 252 943 edited reads that were assigned to species-level operational taxonomic units (OTUs) and standardised for sequencing depth by random sampling. Microbial diversity was compared within vs between twin pairs and by case–control status. Results: The number of unique OTUs was more similar within twin pairs compared with randomly paired participants ( P =0.0004). The AYAHL cases had fewer unique OTUs compared with their co-twin controls (338 vs 369, P =0.015); this difference was not significant (169 vs 183, P =0.10) when restricted to abundant OTUs. Conclusion: In this small study, AYAHL survivors appear to have a deficit of rare gut microbes. Further work is needed to determine if reduced microbial diversity is a consequence of the disease, its treatment, or a particularly hygienic environment.
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/bjc.2013.60