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Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins
Background: Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity. Methods: We investigated whether fecal microbial d...
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| Published in: | British journal of cancer 2013-03, Vol.108 (5), p.1163-1167 |
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| cites | cdi_FETCH-LOGICAL-c575t-f7958e0b5f04b136fe26c6fa94a2cddbaf14f16d3e40902f6c28d6bf19b2639e3 |
| container_end_page | 1167 |
| container_issue | 5 |
| container_start_page | 1163 |
| container_title | British journal of cancer |
| container_volume | 108 |
| creator | Cozen, W Yu, G Gail, M H Ridaura, V K Nathwani, B N Hwang, A E Hamilton, A S Mack, T M Gordon, J I Goedert, J J |
| description | Background:
Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity.
Methods:
We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their unaffected co-twin controls. Pyrosequencing of fecal bacterial 16S rRNA amplicons yielded 252 943 edited reads that were assigned to species-level operational taxonomic units (OTUs) and standardised for sequencing depth by random sampling. Microbial diversity was compared within
vs
between twin pairs and by case–control status.
Results:
The number of unique OTUs was more similar within twin pairs compared with randomly paired participants (
P
=0.0004). The AYAHL cases had fewer unique OTUs compared with their co-twin controls (338
vs
369,
P
=0.015); this difference was not significant (169
vs
183,
P
=0.10) when restricted to abundant OTUs.
Conclusion:
In this small study, AYAHL survivors appear to have a deficit of rare gut microbes. Further work is needed to determine if reduced microbial diversity is a consequence of the disease, its treatment, or a particularly hygienic environment. |
| doi_str_mv | 10.1038/bjc.2013.60 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3619077</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1694968971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c575t-f7958e0b5f04b136fe26c6fa94a2cddbaf14f16d3e40902f6c28d6bf19b2639e3</originalsourceid><addsrcrecordid>eNqFkc1rFDEYh4Modq2evEtAhILONh8zyaQHoRRrhYIXPYdMPrZZZ5I1mVmZ_94Mu9YqgqeQvE9-ed88ALzEaI0Rbc-7rV4ThOmaoUdghRtKKtwS_hisEEK8QoKgE_As523ZCtTyp-CE0LqmjNcrYK6tVj0cvE6x83FU0Pi9TdmPM_QB5int_T6mDKODysTeZm3DeD7HKWzKwdSP8CaazbfC9vOwu4uDuoAK5nEy83Jn_OFDfg6eONVn--K4noKv1x--XN1Ut58_frq6vK10w5uxclw0rUVd41DdYcqcJUwzp0StiDamUw7XDjNDbV0GIY5p0hrWOSw6wqiw9BS8P-Tupm6wZuk0qV7ukh9UmmVUXv5ZCf5ObuJeUoYF4rwEnB0DUvw-2TzKwZeB-14FG6csMRO1YK3g-P8oxS0Txc-S-vovdBunFMpPLBQXjPAWFertgSomck7W3feNkVxEyyJaLqIlW-hXD0e9Z3-ZLcCbI6ByMeySCtrn3xzHrGAL9-7A5VIKG5seNPePd38ChKnA6w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1317962780</pqid></control><display><type>article</type><title>Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins</title><source>PubMed Central</source><creator>Cozen, W ; Yu, G ; Gail, M H ; Ridaura, V K ; Nathwani, B N ; Hwang, A E ; Hamilton, A S ; Mack, T M ; Gordon, J I ; Goedert, J J</creator><creatorcontrib>Cozen, W ; Yu, G ; Gail, M H ; Ridaura, V K ; Nathwani, B N ; Hwang, A E ; Hamilton, A S ; Mack, T M ; Gordon, J I ; Goedert, J J</creatorcontrib><description>Background:
Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity.
Methods:
We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their unaffected co-twin controls. Pyrosequencing of fecal bacterial 16S rRNA amplicons yielded 252 943 edited reads that were assigned to species-level operational taxonomic units (OTUs) and standardised for sequencing depth by random sampling. Microbial diversity was compared within
vs
between twin pairs and by case–control status.
Results:
The number of unique OTUs was more similar within twin pairs compared with randomly paired participants (
P
=0.0004). The AYAHL cases had fewer unique OTUs compared with their co-twin controls (338
vs
369,
P
=0.015); this difference was not significant (169
vs
183,
P
=0.10) when restricted to abundant OTUs.
Conclusion:
In this small study, AYAHL survivors appear to have a deficit of rare gut microbes. Further work is needed to determine if reduced microbial diversity is a consequence of the disease, its treatment, or a particularly hygienic environment.</description><identifier>ISSN: 0007-0920</identifier><identifier>ISSN: 1532-1827</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2013.60</identifier><identifier>PMID: 23443674</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/698/2741/2135 ; 692/699/67/1990/291/1556 ; 692/700/478/174 ; Adolescent ; Adult ; Bacteria - genetics ; Bacteria - isolation & purification ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cancer Research ; Drug Resistance ; Epidemiology ; Feces ; Feces - microbiology ; Hematologic and hematopoietic diseases ; Hodgkin Disease - microbiology ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma ; Male ; Medical sciences ; Medicine ; Metagenome ; Microbiota ; Molecular Medicine ; Oncology ; Short Communication ; Survivors ; Tumors ; Twin studies ; Twins ; Young Adult ; Young adults</subject><ispartof>British journal of cancer, 2013-03, Vol.108 (5), p.1163-1167</ispartof><rights>The Author(s) 2013</rights><rights>2014 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Mar 19, 2013</rights><rights>Copyright © 2013 Cancer Research UK 2013 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-f7958e0b5f04b136fe26c6fa94a2cddbaf14f16d3e40902f6c28d6bf19b2639e3</citedby><cites>FETCH-LOGICAL-c575t-f7958e0b5f04b136fe26c6fa94a2cddbaf14f16d3e40902f6c28d6bf19b2639e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619077/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619077/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27166744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23443674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cozen, W</creatorcontrib><creatorcontrib>Yu, G</creatorcontrib><creatorcontrib>Gail, M H</creatorcontrib><creatorcontrib>Ridaura, V K</creatorcontrib><creatorcontrib>Nathwani, B N</creatorcontrib><creatorcontrib>Hwang, A E</creatorcontrib><creatorcontrib>Hamilton, A S</creatorcontrib><creatorcontrib>Mack, T M</creatorcontrib><creatorcontrib>Gordon, J I</creatorcontrib><creatorcontrib>Goedert, J J</creatorcontrib><title>Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity.
Methods:
We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their unaffected co-twin controls. Pyrosequencing of fecal bacterial 16S rRNA amplicons yielded 252 943 edited reads that were assigned to species-level operational taxonomic units (OTUs) and standardised for sequencing depth by random sampling. Microbial diversity was compared within
vs
between twin pairs and by case–control status.
Results:
The number of unique OTUs was more similar within twin pairs compared with randomly paired participants (
P
=0.0004). The AYAHL cases had fewer unique OTUs compared with their co-twin controls (338
vs
369,
P
=0.015); this difference was not significant (169
vs
183,
P
=0.10) when restricted to abundant OTUs.
Conclusion:
In this small study, AYAHL survivors appear to have a deficit of rare gut microbes. Further work is needed to determine if reduced microbial diversity is a consequence of the disease, its treatment, or a particularly hygienic environment.</description><subject>692/698/2741/2135</subject><subject>692/699/67/1990/291/1556</subject><subject>692/700/478/174</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Bacteria - genetics</subject><subject>Bacteria - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Feces</subject><subject>Feces - microbiology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hodgkin Disease - microbiology</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Metagenome</subject><subject>Microbiota</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Short Communication</subject><subject>Survivors</subject><subject>Tumors</subject><subject>Twin studies</subject><subject>Twins</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0007-0920</issn><issn>1532-1827</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkc1rFDEYh4Modq2evEtAhILONh8zyaQHoRRrhYIXPYdMPrZZZ5I1mVmZ_94Mu9YqgqeQvE9-ed88ALzEaI0Rbc-7rV4ThOmaoUdghRtKKtwS_hisEEK8QoKgE_As523ZCtTyp-CE0LqmjNcrYK6tVj0cvE6x83FU0Pi9TdmPM_QB5int_T6mDKODysTeZm3DeD7HKWzKwdSP8CaazbfC9vOwu4uDuoAK5nEy83Jn_OFDfg6eONVn--K4noKv1x--XN1Ut58_frq6vK10w5uxclw0rUVd41DdYcqcJUwzp0StiDamUw7XDjNDbV0GIY5p0hrWOSw6wqiw9BS8P-Tupm6wZuk0qV7ukh9UmmVUXv5ZCf5ObuJeUoYF4rwEnB0DUvw-2TzKwZeB-14FG6csMRO1YK3g-P8oxS0Txc-S-vovdBunFMpPLBQXjPAWFertgSomck7W3feNkVxEyyJaLqIlW-hXD0e9Z3-ZLcCbI6ByMeySCtrn3xzHrGAL9-7A5VIKG5seNPePd38ChKnA6w</recordid><startdate>20130319</startdate><enddate>20130319</enddate><creator>Cozen, W</creator><creator>Yu, G</creator><creator>Gail, M H</creator><creator>Ridaura, V K</creator><creator>Nathwani, B N</creator><creator>Hwang, A E</creator><creator>Hamilton, A S</creator><creator>Mack, T M</creator><creator>Gordon, J I</creator><creator>Goedert, J J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20130319</creationdate><title>Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins</title><author>Cozen, W ; Yu, G ; Gail, M H ; Ridaura, V K ; Nathwani, B N ; Hwang, A E ; Hamilton, A S ; Mack, T M ; Gordon, J I ; Goedert, J J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-f7958e0b5f04b136fe26c6fa94a2cddbaf14f16d3e40902f6c28d6bf19b2639e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>692/698/2741/2135</topic><topic>692/699/67/1990/291/1556</topic><topic>692/700/478/174</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Bacteria - genetics</topic><topic>Bacteria - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Feces</topic><topic>Feces - microbiology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hodgkin Disease - microbiology</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Metagenome</topic><topic>Microbiota</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Short Communication</topic><topic>Survivors</topic><topic>Tumors</topic><topic>Twin studies</topic><topic>Twins</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cozen, W</creatorcontrib><creatorcontrib>Yu, G</creatorcontrib><creatorcontrib>Gail, M H</creatorcontrib><creatorcontrib>Ridaura, V K</creatorcontrib><creatorcontrib>Nathwani, B N</creatorcontrib><creatorcontrib>Hwang, A E</creatorcontrib><creatorcontrib>Hamilton, A S</creatorcontrib><creatorcontrib>Mack, T M</creatorcontrib><creatorcontrib>Gordon, J I</creatorcontrib><creatorcontrib>Goedert, J J</creatorcontrib><collection>Springer Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cozen, W</au><au>Yu, G</au><au>Gail, M H</au><au>Ridaura, V K</au><au>Nathwani, B N</au><au>Hwang, A E</au><au>Hamilton, A S</au><au>Mack, T M</au><au>Gordon, J I</au><au>Goedert, J J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2013-03-19</date><risdate>2013</risdate><volume>108</volume><issue>5</issue><spage>1163</spage><epage>1167</epage><pages>1163-1167</pages><issn>0007-0920</issn><issn>1532-1827</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity.
Methods:
We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their unaffected co-twin controls. Pyrosequencing of fecal bacterial 16S rRNA amplicons yielded 252 943 edited reads that were assigned to species-level operational taxonomic units (OTUs) and standardised for sequencing depth by random sampling. Microbial diversity was compared within
vs
between twin pairs and by case–control status.
Results:
The number of unique OTUs was more similar within twin pairs compared with randomly paired participants (
P
=0.0004). The AYAHL cases had fewer unique OTUs compared with their co-twin controls (338
vs
369,
P
=0.015); this difference was not significant (169
vs
183,
P
=0.10) when restricted to abundant OTUs.
Conclusion:
In this small study, AYAHL survivors appear to have a deficit of rare gut microbes. Further work is needed to determine if reduced microbial diversity is a consequence of the disease, its treatment, or a particularly hygienic environment.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23443674</pmid><doi>10.1038/bjc.2013.60</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | British journal of cancer, 2013-03, Vol.108 (5), p.1163-1167 |
| issn | 0007-0920 1532-1827 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3619077 |
| source | PubMed Central |
| subjects | 692/698/2741/2135 692/699/67/1990/291/1556 692/700/478/174 Adolescent Adult Bacteria - genetics Bacteria - isolation & purification Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Drug Resistance Epidemiology Feces Feces - microbiology Hematologic and hematopoietic diseases Hodgkin Disease - microbiology Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Male Medical sciences Medicine Metagenome Microbiota Molecular Medicine Oncology Short Communication Survivors Tumors Twin studies Twins Young Adult Young adults |
| title | Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins |
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