Utility of risk-weighted surgical–pathological factors in early-stage cervical cancer

Background: Surgical–pathological risk factors were evaluated by weighting the magnitude of significance of multiple risk factors correlating to survival and treatment response in cervical cancer. Methods: Multivariate analysis was performed for survival outcomes entering seven pathological factors...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 2013-04, Vol.108 (6), p.1348-1357
Main Authors: Matsuo, K, Mabuchi, S, Okazawa, M, Matsumoto, Y, Tsutsui, T, Fujita, M, Kamiura, S, Ogawa, K, Morrow, C P, Kimura, T
Format: Article
Language:English
Subjects:
692/499
692/699/67/1517/1371
692/700/139/422
692/700/565/545/546
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Carcinoma, Adenosquamous - mortality
Carcinoma, Adenosquamous - pathology
Carcinoma, Adenosquamous - therapy
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Cervical cancer
Chemoradiotherapy
Chemotherapy, Adjuvant
Combined Modality Therapy
Drug Resistance
Epidemiology
Female
Female genital diseases
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Hysterectomy
Invasions
Medical sciences
Middle Aged
Molecular Diagnostics
Molecular Medicine
Neoplasm Staging
Oncology
Prognosis
Radiotherapy
Radiotherapy, Adjuvant
Risk Factors
Survival
Survival Rate
Tumors
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Surgical–pathological risk factors were evaluated by weighting the magnitude of significance of multiple risk factors correlating to survival and treatment response in cervical cancer. Methods: Multivariate analysis was performed for survival outcomes entering seven pathological factors obtained from 540 radical hysterectomy specimens in stage IA2-IIB cervical cancer cases. Hazard ratio (HR) in each risk factor was determined, and the sum of HR scores for the corresponding risk factors was determined per case. Survival curves and postoperative treatment response (concurrent chemoradiotherapy (CCRT) vs radiotherapy alone) were evaluated based on the extent of HR-weighted scores. Results: Hazard ratios for risk factors relating to disease-free survival (DFS) was: lympho-vascular space invasion 3.95, nodal metastasis 3.88, adenocarcinoma 3.40, large tumour 2.36, positive margin 1.99, deep stromal invasion 1.29, and parametria invasion 1.21. The HR-weighted scoring method showed a high predictive value for recurrence (area-under-curve 0.836, P
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2013.78