Controlling Spatial Organization of Multiple Cell Types in Defined 3D Geometries

A simple method to control spatial organizations of multiple cell types in predefined geometries by using poly(N‐isopropylacrylamide)‐based dynamic microwells is described. Dynamic microwells are used to pattern two different cell types in a spatially controlled manner by exploiting their shape chan...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) 2012-11, Vol.24 (41), p.5543-5547
Main Authors: Tekin, Halil, Sanchez, Jefferson G., Landeros, Christian, Dubbin, Karen, Langer, Robert, Khademhosseini, Ali
Format: Article
Language:English
Subjects:
3T3 Cells
Acrylamides - chemistry
Acrylic Resins
Animals
biological complexity
cancer biology
Cell Culture Techniques
cell patterning
developmental biology
drug discovery
Green Fluorescent Proteins - genetics
Green Fluorescent Proteins - metabolism
Hep G2 Cells
Human Umbilical Vein Endothelial Cells
Humans
Mice
Microfluidic Analytical Techniques
microstructures
multicellular organization
Polymers - chemistry
Temperature
thermoresponsive platforms
Tissue Engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A simple method to control spatial organizations of multiple cell types in predefined geometries by using poly(N‐isopropylacrylamide)‐based dynamic microwells is described. Dynamic microwells are used to pattern two different cell types in a spatially controlled manner by exploiting their shape changing properties at two different temperatures. Both spatial organization of two different cell types and control of pattern geometry are achieved with circular and square dynamic microwells.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201201805