Ethanol treatment of tendon allografts : a potential HIV inactivating procedure

The penetration rate of ethanol in human tendons was studied to in order to define the conditions which were necessary to achieve an inactivating concentration against the Human Immunodeficiency Virus (HIV) within the tendon. The rate of alcohol penetration was found to be slow and did not differ wi...

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Bibliographic Details
Published in:International orthopaedics 1998, Vol.22 (4), p.252-254
Main Authors: ANASTASESCOU, M, CORNU, O, BANSE, X, KÖNIG, J, HASSOUN, A, DELLOYE, C
Format: Article
Language:English
Subjects:
AIDS/HIV
Anti-Infective Agents, Local - analysis
Anti-Infective Agents, Local - pharmacokinetics
Biological and medical sciences
Drug Evaluation, Preclinical
Ethanol - analysis
Ethanol - pharmacokinetics
HIV - drug effects
Humans
Infection Control - methods
Medical sciences
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Tendons - chemistry
Tendons - drug effects
Tendons - transplantation
Tendons - virology
Time Factors
Tissue Distribution
Tissue Preservation - methods
Transplantation, Homologous
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Summary:The penetration rate of ethanol in human tendons was studied to in order to define the conditions which were necessary to achieve an inactivating concentration against the Human Immunodeficiency Virus (HIV) within the tendon. The rate of alcohol penetration was found to be slow and did not differ with different types of tendons. An average ethanol concentration of 14% (v/v) was measured in human tendons after they had been immersed for 2 h in 70% (v/v) ethanol, and a concentration of 19% (v/v) was reached after 3 h. Ethanol immersion of human tendons may represent an additional safety procedure in inactivating the HIV virus provided the duration is at least 3 h.
ISSN:0341-2695
1432-5195
DOI:10.1007/s002640050253