α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property : A Mechanistic Study

Cratoxylum arborescens (Vahl) Blume is an Asian herbal medicine with versatile ethnobiological properties including treatment of gastric ulcer. This study evaluated the antiulcerogenic mechanism(s) of α-mangostin (AM) in a rat model of ulcer. AM is a prenylated xanthone derived through biologically...

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Published in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-10
Main Authors: Sidahmed, Heyam M. A., Abdel Wahab, Siddig Ibrahim, Mohan, Syam, Abdulla, Mahmood Ameen, Mohamed Elhassan Taha, Manal, Hashim, Najihah Mohd, Hadi, A. Hamid A., Vadivelu, Jamunarani, Loke Fai, Mun, Rahmani, Mawardi, Yahayu, Maizatulakmal
Format: Article
Language:English
Subjects:
Acidity
Antioxidants
Biochemistry
Cyclooxygenase-2
Cytotoxicity
Ethanol
Fractionation
Gastric juice
Glutathione
Heat shock proteins
Helicobacter pylori
Herbal medicine
Hsp70 protein
Laboratory animals
Lesions
Lipid peroxidation
Malondialdehyde
Medicine
Minimum inhibitory concentration
Mucus
Nitric oxide
Nonsteroidal anti-inflammatory drugs
Peroxidation
Sulfhydryl groups
Ulcers
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Summary:Cratoxylum arborescens (Vahl) Blume is an Asian herbal medicine with versatile ethnobiological properties including treatment of gastric ulcer. This study evaluated the antiulcerogenic mechanism(s) of α-mangostin (AM) in a rat model of ulcer. AM is a prenylated xanthone derived through biologically guided fractionation of C. arborescens. Rats were orally pretreated with AM and subsequently exposed to acute gastric lesions induced by ethanol. Following treatment, ulcer index, gastric juice acidity, mucus content, histological and immunohistochemical analyses, glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and nonprotein sulfhydryl groups (NP-SH) were evaluated. The anti-Helicobacter pylori, cyclooxygenase-2 (COX-2) inhibitory effect, and antioxidant activity of AM were also investigated in vitro. AM (10 and 30 mg/kg) inhibited significantly (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/450840