Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide

Andrographis paniculata (Burm. F) Nees, generally known as “king of bitters,” is an herbaceous plant in the family Acanthaceae. In China, India, Thailand, and Malaysia, this plant has been widely used for treating sore throat, flu, and upper respiratory tract infections. Andrographolide, a major bio...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-16
Main Authors: Sheu, Joen-Rong, Lee, Jie-Jen, Hsieh, Cheng-Ying, Jayakumar, Thanasekaran
Format: Article
Language:English
Subjects:
Activation
Andrographis paniculata
Antidiabetics
Antioxidants
Arthritis
Asthma
Bioactive compounds
Cancer
Cardiovascular diseases
Chemistry
Chromatography
Diabetes
Diabetes mellitus
HIV
Human immunodeficiency virus
Infertility
Inflammation
NF-κB protein
Pharmaceutical sciences
Pharmacology
Pharyngitis
Pharynx
Qualitative research
Respiratory tract
Respiratory tract diseases
Review
Rodents
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Summary:Andrographis paniculata (Burm. F) Nees, generally known as “king of bitters,” is an herbaceous plant in the family Acanthaceae. In China, India, Thailand, and Malaysia, this plant has been widely used for treating sore throat, flu, and upper respiratory tract infections. Andrographolide, a major bioactive chemical constituent of the plant, has shown anticancer potential in various investigations. Andrographolide and its derivatives have anti-inflammatory effects in experimental models asthma, stroke, and arthritis. In recent years, pharmaceutical chemists have synthesized numerous andrographolide derivatives, which exhibit essential pharmacological activities such as those that are anti-inflammatory, antibacterial, antitumor, antidiabetic, anti-HIV, antifeedant, and antiviral. However, what is noteworthy about this paper is summarizing the effects of andrographolide against cardiovascular disease, platelet activation, infertility, and NF-κB activation. Therefore, this paper is intended to provide evidence reported in relevant literature on qualitative research to assist scientists in isolating and characterizing bioactive compounds.
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/846740