Measurement of the bioactivity of interleukin and tumour necrosis factor in synovial fluid of Kashin-Beck disease: Kashin-Beck disease

We studied the bioactivity of interleukin (IL-1) and tumour necrosis factor (TNF) in the synovial fluid of 12 patients with Kashin-Beck disease (KBD), 8 patients with osteoarthritis (OA) and 8 normal controls. C57 female mouse T cell proliferation method was used to test the bioactivity of IL-1, and...

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Bibliographic Details
Published in:International orthopaedics 2001, Vol.25 (3), p.162-163
Main Authors: Yang, T F, Wang, G, Tong, W, Gong, Q, Cheng, Y
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Diseases of the osteoarticular system
Female
Humans
Interleukin-1 - metabolism
Male
Medical sciences
Middle Aged
Miscellaneous. Osteoarticular involvement in other diseases
Original Paper
Osteoarthritis - metabolism
Synovial Fluid - chemistry
Tumor Necrosis Factor-alpha - metabolism
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Summary:We studied the bioactivity of interleukin (IL-1) and tumour necrosis factor (TNF) in the synovial fluid of 12 patients with Kashin-Beck disease (KBD), 8 patients with osteoarthritis (OA) and 8 normal controls. C57 female mouse T cell proliferation method was used to test the bioactivity of IL-1, and lethality method with L929 cells to test the bioactivity of TNF. The bioactivities of IL-1 and TNF in the synovial fluid from patients with KBD were higher than those in the synovial fluid of osteoarthritis and normal controls, indicating the participation of IL-1 and TNF in the pathogenesis of KBD.
ISSN:0341-2695
1432-5195
DOI:10.1007/s002640100243