How adenylate cyclase choreographs the pas de deux of the receptors heteromerization dance

Graphical abstract Highlights ► Heteromers form through electrostatic interactions of linear motifs located in disordered regions of receptors’ proteins. ► Activation/inhibition of adenylate cyclase by Adenosine/Dopamine controls the production of cAMP which activates PKA. ► Phosphorylation of Ser/T...

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Bibliographic Details
Published in:Neuroscience 2013-05, Vol.238, p.335-344
Main Authors: Woods, A.S, Jackson, S.N
Format: Article
Language:English
Subjects:
adenosine receptor
Adenylyl Cyclases - metabolism
Biological and medical sciences
Cyclic AMP-Dependent Protein Kinases - metabolism
disordered proteins
dopamine receptors
Epitopes - metabolism
Fundamental and applied biological sciences. Psychology
Models, Molecular
Neurology
noncovalent interactions
Phosphorylation
Protein Conformation
Protein Multimerization - physiology
receptor heteromers
Receptors, G-Protein-Coupled - metabolism
Vertebrates: nervous system and sense organs
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Summary:Graphical abstract Highlights ► Heteromers form through electrostatic interactions of linear motifs located in disordered regions of receptors’ proteins. ► Activation/inhibition of adenylate cyclase by Adenosine/Dopamine controls the production of cAMP which activates PKA. ► Phosphorylation of Ser/Thr by cAMP-activated PKA in the Arginine-rich epitope controls the stability of heteromers. ► Dopaminergic neurotransmission, through cAMP-dependent PKA slows down heteromerization. ► In heteromerization, phosphorylation is not just an on/off switch , by weakening noncovalent bonds, it acts like a rheostat.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.02.006