Effect of dutasteride on clinical progression of benign prostatic hyperplasia in asymptomatic men with enlarged prostate: a post hoc analysis of the REDUCE study

Objective To assess the role of dutasteride in preventing clinical progression of benign prostatic hyperplasia in asymptomatic men with larger prostates.Design Post hoc analysis of four year, double blind Reduction by Dutasteride of Prostate Cancer Events (REDUCE) studyParticipants 1617 men randomis...

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Bibliographic Details
Published in:BMJ (Online) 2013-04, Vol.346 (7908), p.13-13
Main Authors: Toren, Paul, Margel, David, Kulkarni, Girish, Finelli, Antonio, Zlotta, Alexandre, Fleshner, Neil
Format: Article
Language:English
Subjects:
5-alpha Reductase Inhibitors - administration & dosage
5-alpha Reductase Inhibitors - adverse effects
Aged
Androgens
Antigens
Asymptomatic Diseases
Azasteroids - administration & dosage
Azasteroids - adverse effects
Benign
Clinical trials
Disease prevention
Disease Progression
Double-Blind Method
Drug Monitoring - methods
Drugs
Dutasteride
Erectile Dysfunction - chemically induced
Genital diseases
Humans
Hyperplasia
Male
Men
Mens health
Middle Aged
Placebos
Post hoc
Prostate
Prostate - drug effects
Prostate - pathology
Prostate cancer
Prostate-Specific Antigen - blood
Prostatic hyperplasia
Prostatic Hyperplasia - blood
Prostatic Hyperplasia - complications
Prostatic Hyperplasia - diagnosis
Prostatic Hyperplasia - drug therapy
Prostatic Hyperplasia - physiopathology
Regression Analysis
Retention
Risk Assessment
Surgery
Symptoms
Treatment Outcome
Ultrasonic imaging
Urinary retention
Urinary Retention - etiology
Urinary Retention - physiopathology
Urinary Retention - prevention & control
Urinary tract
Urinary tract diseases
Urinary tract infections
Urinary Tract Infections - etiology
Urinary Tract Infections - physiopathology
Urinary Tract Infections - prevention & control
Urogenital system
Urology
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Description
Summary:Objective To assess the role of dutasteride in preventing clinical progression of benign prostatic hyperplasia in asymptomatic men with larger prostates.Design Post hoc analysis of four year, double blind Reduction by Dutasteride of Prostate Cancer Events (REDUCE) studyParticipants 1617 men randomised to dutasteride or placebo with a prostate size >40 mL and baseline International Prostate Symptom Score (IPSS)
ISSN:0959-8138
1756-1833
0959-8146
1756-1833
DOI:10.1136/bmj.f2109