LKB1 and AMPK and the cancer-metabolism link - ten years after

The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003. This finding represented the first clear link between...

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Bibliographic Details
Published in:BMC biology 2013-04, Vol.11 (1), p.36-36, Article 36
Main Authors: Hardie, D Grahame, Alessi, Dario R
Format: Article
Language:English
Subjects:
AMP-Activated Protein Kinases - metabolism
Cancer
Cell Transformation, Neoplastic - pathology
Colleges & universities
Energy Metabolism
Enzymes
Genetic aspects
Health aspects
Humans
Kinases
Medical research
Neoplasms - enzymology
Neoplasms - metabolism
Neoplasms - prevention & control
Neoplasms - therapy
Physiological aspects
Protein kinases
Protein Serine-Threonine Kinases - metabolism
Proteins
Review
Signal Transduction
Tumor suppressor genes
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Summary:The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003. This finding represented the first clear link between AMPK and cancer. Here we briefly discuss how this discovery came about, and describe some of the insights, especially into the role of AMPK in cancer, that have followed from it.
ISSN:1741-7007
1741-7007
DOI:10.1186/1741-7007-11-36