Otoprotective effects of erythropoietin on Cdh23erl/erl mice

Highlights ► The Cdh23erl/erl mice are a novel mouse model for progressive hearing loss. ► We evaluated EPO as an effective as an otoprotectant on the Cdh23erl/erl mice. ► EPO can protect hearing by 20–30 dB in the Cdh23erl/erl mice.

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Bibliographic Details
Published in:Neuroscience 2013-05, Vol.237, p.1-6
Main Authors: Han, F, Yu, H, Zheng, T, Ma, X, Zhao, X, Li, P, Le, L, Su, Y, Zheng, Q.Y
Format: Article
Language:English
Subjects:
3,4-Dihydroxyphenylacetic Acid - metabolism
ABR
Acoustic Stimulation
Analysis of Variance
Animals
Auditory Threshold - drug effects
Auditory Threshold - physiology
Biological and medical sciences
Cadherins - genetics
Cell Count
Chi-Square Distribution
Cochlea - cytology
Cochlea - drug effects
Disease Models, Animal
DPOAE
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
erythropoietin
Erythropoietin - therapeutic use
Evoked Potentials, Auditory, Brain Stem - drug effects
Evoked Potentials, Auditory, Brain Stem - genetics
Fundamental and applied biological sciences. Psychology
genetics
Hair Cells, Auditory - drug effects
Hair Cells, Auditory - metabolism
hearing loss
Hearing Loss, Sensorineural - drug therapy
Hearing Loss, Sensorineural - genetics
Mice
Mice, Transgenic
mouse model
Mutation - genetics
Neurology
Otoacoustic Emissions, Spontaneous - drug effects
Otoacoustic Emissions, Spontaneous - genetics
Time Factors
Vertebrates: nervous system and sense organs
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Summary:Highlights ► The Cdh23erl/erl mice are a novel mouse model for progressive hearing loss. ► We evaluated EPO as an effective as an otoprotectant on the Cdh23erl/erl mice. ► EPO can protect hearing by 20–30 dB in the Cdh23erl/erl mice.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.01.052