Expression of the PXR gene in various types of cancer and drug resistance

Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. PXR is a key xenobiotic receptor that regulates the expression of genes implicated in drug metabolism, detoxification and clearance, including drug metabolizing enzymes and transporte...

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Published in:Oncology letters 2013-04, Vol.5 (4), p.1093-1100
Main Authors: QIAO, ENQI, JI, MINGHUA, WU, JIANZHONG, MA, RONG, ZHANG, XIAOHUA, HE, YUEJUN, ZHA, QUANBIN, SONG, XUE, ZHU, LI-WEI, TANG, JINHAI
Format: Article
Language:English
Subjects:
Apoptosis
Binding sites
Breast cancer
cancer
Colorectal cancer
Drug resistance
Enzymes
Homeostasis
Ligands
Metabolism
multidrug resistance
Multidrug resistant organisms
Oncology
pregnane X receptor
Prescription drugs
Proteins
Review
Studies
tumor cell apoptosis
Tumors
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Summary:Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. PXR is a key xenobiotic receptor that regulates the expression of genes implicated in drug metabolism, detoxification and clearance, including drug metabolizing enzymes and transporters, suggesting that it is significant in the drug resistance of cancer cells. PXR is expressed in a wide range of tissues in the human body. Studies have demonstrated that PXR is expressed in a variety of tumor types, correlating not only with drug resistance but also with the cell proliferation, apoptosis and prognosis of cancer. The purpose of the present review is to provide a comprehensive review of PXR and its potential roles in multidrug resistance and the biological characteristics of PXR-positive tumors.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2013.1149