Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

• Published in: Brain pathology (Zurich, Switzerland) Switzerland), 2013-05, Vol.23 (3), p.303-310
• Main Authors: Sengillo, Jesse D., Winkler, Ethan A., Walker, Corey T., Sullivan, John S., Johnson, Mahlon, Zlokovic, Berislav V.
• Format: Article
• Language: English
• Subjects: Aged; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Blood; Blood Proteins - metabolism; Blood Vessels - pathology; Blood-brain barrier; Blood-Brain Barrier - pathology; Cell Count; Cerebral Cortex - pathology; Cerebrovascular Circulation - physiology; Female; Fibrin - metabolism; Fluorescent Antibody Technique; Hippocampus - pathology; Humans; Image Processing, Computer-Assisted; Immunoglobulin G - metabolism; Male; Middle Aged; Myocytes, Smooth Muscle - pathology; Neurology; pericytes; Pericytes - pathology; Proteins; Rodents
• ISSN: 1015-6305; 1750-3639
• DOI: 10.1111/bpa.12004

Neurovascular dysfunction contributes to Alzheimer's disease (AD). Cerebrovascular abnormalities and blood–brain barrier (BBB) damage have been shown in AD. The BBB dysfunction can lead to leakage of potentially neurotoxic plasma components in brain that may contribute to neuronal injury. Pericytes are integral in maintaining the BBB integrity. Pericyte‐deficient mice develop a chronic BBB damage preceding neuronal injury. Moreover, loss of pericytes was associated with BBB breakdown in patients with amyotrophic lateral sclerosis. Here, we demonstrate a decrease in mural vascular cells in AD, and show that pericyte number and coverage in the cortex and hippocampus of AD subjects compared with neurologically intact controls are reduced by 59% and 60% (P