Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging

High resolution compressed sensing hyperpolarized 13C magnetic resonance spectroscopic imaging was applied in orthotopic human glioblastoma xenografts for quantitative assessment of spatial variations in 13C metabolic profiles and comparison with histopathology. A new compressed sensing sampling des...

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Published in:Magnetic resonance in medicine 2013-07, Vol.70 (1), p.33-39
Main Authors: Park, Ilwoo, Hu, Simon, Bok, Robert, Ozawa, Tomoko, Ito, Motokazu, Mukherjee, Joydeep, Phillips, Joanna J., James, C. David, Pieper, Russell O., Ronen, Sabrina M., Vigneron, Daniel B., Nelson, Sarah J.
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - metabolism
Brain Neoplasms - metabolism
Carbon Isotopes
Cell Line, Tumor
compressed sensing
Data Compression - methods
dynamic nuclear polarization
glioblastoma
Glioblastoma - metabolism
Humans
hyperpolarized 13C MRSI
Imaging, Three-Dimensional - methods
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Male
Molecular Imaging - methods
Neoplasm Proteins - metabolism
pyruvate
Rats
Rats, Nude
Reproducibility of Results
Sensitivity and Specificity
Tissue Distribution
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container_end_page 39
container_issue 1
container_start_page 33
container_title Magnetic resonance in medicine
container_volume 70
creator Park, Ilwoo
Hu, Simon
Bok, Robert
Ozawa, Tomoko
Ito, Motokazu
Mukherjee, Joydeep
Phillips, Joanna J.
James, C. David
Pieper, Russell O.
Ronen, Sabrina M.
Vigneron, Daniel B.
Nelson, Sarah J.
description High resolution compressed sensing hyperpolarized 13C magnetic resonance spectroscopic imaging was applied in orthotopic human glioblastoma xenografts for quantitative assessment of spatial variations in 13C metabolic profiles and comparison with histopathology. A new compressed sensing sampling design with a factor of 3.72 acceleration was implemented to enable a factor of 4 increase in spatial resolution. Compressed sensing 3D 13C magnetic resonance spectroscopic imaging data were acquired from a phantom and 10 tumor‐bearing rats following injection of hyperpolarized [1‐13C]‐pyruvate using a 3T scanner. The 13C metabolic profiles were compared with hematoxylin and eosin staining and carbonic anhydrase 9 staining. The high‐resolution compressed sensing 13C magnetic resonance spectroscopic imaging data enabled the differentiation of distinct 13C metabolite patterns within abnormal tissues with high specificity in similar scan times compared to the fully sampled method. The results from pathology confirmed the different characteristics of 13C metabolic profiles between viable, non‐necrotic, nonhypoxic tumor, and necrotic, hypoxic tissue. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
doi_str_mv 10.1002/mrm.24434
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source Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list)
subjects Animals
Biomarkers, Tumor - metabolism
Brain Neoplasms - metabolism
Carbon Isotopes
Cell Line, Tumor
compressed sensing
Data Compression - methods
dynamic nuclear polarization
glioblastoma
Glioblastoma - metabolism
Humans
hyperpolarized 13C MRSI
Imaging, Three-Dimensional - methods
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Male
Molecular Imaging - methods
Neoplasm Proteins - metabolism
pyruvate
Rats
Rats, Nude
Reproducibility of Results
Sensitivity and Specificity
Tissue Distribution
title Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging
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