Serum hyaluronan levels increase with the total number of osteoarthritic joints and are strongly associated with the presence of knee and finger osteoarthritis

Purpose Although serum hyaluronan (HA) levels increase in patients with osteoarthritis (OA), the association between OA severity and elevation of serum HA levels is not clear. Our purpose was to investigate the relationship between serum HA levels and OA in various anatomical sites and to detect whi...

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Bibliographic Details
Published in:International orthopaedics 2013-05, Vol.37 (5), p.925-930
Main Authors: Sasaki, Eiji, Tsuda, Eiichi, Yamamoto, Yuji, Iwasaki, Koei, Inoue, Ryo, Takahashi, Ippei, Sawada, Kaori, Fujita, Hiroshi, Umeda, Takashi, Nakaji, Shigeyuki, Ishibashi, Yasuyuki
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Biomarkers - blood
Comorbidity
Female
Finger Joint - diagnostic imaging
Finger Joint - pathology
Humans
Hyaluronic Acid - blood
Japan - epidemiology
Male
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Orthopedics
Osteoarthritis, Knee - blood
Osteoarthritis, Knee - diagnostic imaging
Osteoarthritis, Knee - epidemiology
Prevalence
Radiography
Severity of Illness Index
Young Adult
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Summary:Purpose Although serum hyaluronan (HA) levels increase in patients with osteoarthritis (OA), the association between OA severity and elevation of serum HA levels is not clear. Our purpose was to investigate the relationship between serum HA levels and OA in various anatomical sites and to detect which joints are strongly correlated with elevated serum HA levels. Methods Seven hundred and ten individuals from the general population who participated in the Iwaki Health Promotion Project in 2008 were involved. Kellgren–Lawrence grade 2 or higher in the knee, hip, lumbar spine, finger and wrist was defined as OA. Serum HA levels were determined on the same day. Spearman’s correlation coefficients between serum HA levels and total number of joints affected by OA were calculated. Linear regression was analysed with serum HA levels as the independent variable; age, gender, presence of OA and intake of supplements were used as dependent variables. Results Prevalence of knee OA was 30.7 %, hip 16.8 %, lumbar spine 65.1 %, wrist 9.0 % and finger 22.0 %. Serum HA levels had a positive correlation with the number of involved joints, and the correlation coefficient was 0.410 ( p  
ISSN:0341-2695
1432-5195
DOI:10.1007/s00264-013-1849-x