Comparison of two purification products of shankha bhasma: A prospective randomized control trial

• Published in: Journal of natural science, biology and medicine biology and medicine, 2013-01, Vol.4 (1), p.160-162
• Main Authors: Ranade, Manjiri, Chary, Dingari
• Format: Article
• Language: English
• Subjects: Family medical history; Gastroesophageal reflux; Methods; Nausea; Origin of Life; Statistical analysis; Studies; Vomiting
• ISSN: 0976-9668; 2229-7707
• DOI: 10.4103/0976-9668.107282

Background: Shankha bhasma is widely used in the treatment of gastroesophageal reflux disease (GERD) patients. Aim: To compare the efficacy of two purification methods of shankha bhasma in relieving GERD symptoms. In method A, purification was done with lemon juice and method B with sour gruel. Materials and Methods: Patients with heartburn since at least four days/week but who did undergo endoscopy to assess esophageal mucosa could participate. In this single-phase, single-center, prospective, randomized control trial, the patients were randomized to receive either shankha bhasma purified by method A or by method B. The primary efficacy variable was the proportion of patients with resolution of heartburn at week 4 and week 8. Design: Single-phase, single-center, prospective, randomized control trial in a hospital setting. Results: Of the total 70 patients who received samples A and B in a randomized double-blind manner, 65% of the patients showed resolution of symptoms in sample A and 28% in sample B at the end of four weeks, whereas, 71% of the patients showed resolution of symptoms in sample A and 31% in sample B at the end of eight weeks; P value was statistically significant for resolution of symptoms (P