Apolipoprotein L1 Risk Variants Associate with Systemic Lupus Erythematosus-Associated Collapsing Glomerulopathy

Collapsing glomerulopathy is a devastating renal disease that primarily affects African Americans and associates with numerous etiologies, such as HIV and autoimmune disease. The presence of APOL1 risk alleles associates with HIV-associated collapsing glomerulopathy, but it is unknown whether these...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Society of Nephrology 2013-05, Vol.24 (5), p.722-725
Main Authors: LARSEN, Christopher P, BEGGS, Marjorie L, SAEED, Mohammad, WALKER, Patrick D
Format: Article
Language:English
Subjects:
African Americans - genetics
Alleles
Apolipoprotein L1
Apolipoproteins - genetics
Apolipoproteins - physiology
Biological and medical sciences
Brief Communications
Cohort Studies
Genotype
Glomerulonephritis
Humans
Kidney Glomerulus - pathology
Lipoproteins, HDL - genetics
Lipoproteins, HDL - physiology
Lupus Erythematosus, Systemic - complications
Lupus Nephritis - etiology
Lupus Nephritis - genetics
Lupus Nephritis - pathology
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Risk
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Collapsing glomerulopathy is a devastating renal disease that primarily affects African Americans and associates with numerous etiologies, such as HIV and autoimmune disease. The presence of APOL1 risk alleles associates with HIV-associated collapsing glomerulopathy, but it is unknown whether these risk alleles also associate with systemic lupus erythematosus (SLE) -associated collapsing glomerulopathy. Here, re-examination of 546 renal biopsies from African-American patients with SLE identified 26 cases of collapsing glomerulopathy, which we genotyped for APOL1 risk alleles using DNA extracted from archived biopsy tissue. APOL1 strongly associated with SLE-associated collapsing glomerulopathy (P
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.2012121180