High expression of ubiquitin-conjugating enzyme 2C (UBE2C) correlates with nasopharyngeal carcinoma progression

Overexpression of ubiquitin-conjugating enzyme 2C (UBE2C) has been detected in many types of human cancers, and is correlated with tumor malignancy. However, the role of UBE2C in human nasopharyngeal carcinoma (NPC) is unclear. In this study, we investigated the role of aberrant UBE2C expression in...

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Bibliographic Details
Published in:BMC cancer 2013-04, Vol.13 (1), p.192-192, Article 192
Main Authors: Shen, Zhihua, Jiang, Xiaofan, Zeng, Chao, Zheng, Shaojiang, Luo, Botao, Zeng, Yumei, Ding, Ranran, Jiang, Hanguo, He, Qiyi, Guo, Junli, Jie, Wei
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Biomarkers, Tumor - metabolism
Carcinoma - metabolism
Carcinoma - secondary
Cell cycle
Cell Cycle Checkpoints
Cell Differentiation
Cell Line, Tumor
Cell Proliferation
Development and progression
Disease Progression
Enzymes
Female
Gene Knockdown Techniques
Humans
Lymphatic Metastasis
Male
Medical research
Metastasis
Middle Aged
Nasopharyngeal cancer
Nasopharyngeal Neoplasms - metabolism
Nasopharyngeal Neoplasms - pathology
Nasopharynx - metabolism
Physiological aspects
Proteins
Tumors
Ubiquitin-Conjugating Enzymes - genetics
Ubiquitin-Conjugating Enzymes - metabolism
Ubiquitin-proteasome system
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Summary:Overexpression of ubiquitin-conjugating enzyme 2C (UBE2C) has been detected in many types of human cancers, and is correlated with tumor malignancy. However, the role of UBE2C in human nasopharyngeal carcinoma (NPC) is unclear. In this study, we investigated the role of aberrant UBE2C expression in the progression of human NPC. Immunohistochemical analysis was performed to detect UBE2C protein in clinical samples of NPC and benign nasopharyngeal tissues, and the association of UBE2C expression with patient clinicopathological characteristics was analyzed. UBEC2 expression profiles were evaluated in cell lines representing varying differentiated stages of NPC and immortalized nasopharyngeal epithelia NP-69 cells using quantitative RT-PCR, western blotting and fluorescent staining. Furthermore, UBE2C was knocked down using RNA interference in these cell lines and proliferation and cell cycle distribution was investigated. Immunohistochemical analysis revealed that UBE2C protein expression levels were higher in NPC tissues than in benign nasopharyngeal tissues (P
ISSN:1471-2407
1471-2407
DOI:10.1186/1471-2407-13-192