Influence of emulsifiers on the characteristics of polyurethane structures used as drug carrier

Background Emulsifiers have a significant role in the emulsion polymerization by reducing the interfacial tension thus increasing the stability of colloidal dispersions of polymer nanostructures. This study evaluates the impact of four emulsifiers on the characteristics of polyurethane hollow struct...

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Published in:BMC chemistry 2013-04, Vol.7 (1), p.66-66, Article 66
Main Authors: Heghes, Alina, Soica, Codruta M, Ardelean, Simona, Ambrus, Rita, Muntean, Danina, Galuscan, Atena, Dragos, Dan, Ionescu, Daniela, Borcan, Florin
Format: Article
Language:English
Subjects:
Agglomeration
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Dispersions
Drug delivery systems
Emulsifiers
Emulsion polymerization
Materials and Polymers
Nanostructure
Polyurethane resins
Research Article
Stability
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cited_by cdi_FETCH-LOGICAL-b549t-609ee8edc4cc8dd94f78e46ac830daa66361eb8b081ad78f76790966ec0296983
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container_start_page 66
container_title BMC chemistry
container_volume 7
creator Heghes, Alina
Soica, Codruta M
Ardelean, Simona
Ambrus, Rita
Muntean, Danina
Galuscan, Atena
Dragos, Dan
Ionescu, Daniela
Borcan, Florin
description Background Emulsifiers have a significant role in the emulsion polymerization by reducing the interfacial tension thus increasing the stability of colloidal dispersions of polymer nanostructures. This study evaluates the impact of four emulsifiers on the characteristics of polyurethane hollow structures used as drug delivery system. Results Polyurethane (PU) structures with high stability and sizes ranging from nano- to micro-scale were obtained by interfacial polyaddition combined with spontaneous emulsification. The pH of PU aqueous solutions (0.1% w/w) was slightly acidic, which is acceptable for products intended to be used on human skin. Agglomerated structures with irregular shapes were observed by scanning electron microscopy. The synthesized structures have melting points between 245-265°C and reveal promising results in different evaluations (TEWL, mexametry) on murine skin. Conclusions In this study hollow PU structures of reduced noxiousness were synthesized, their size and stability being influenced by emulsifiers. Such structures could be used in the pharmaceutical field as future drug delivery systems.
doi_str_mv 10.1186/1752-153X-7-66
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This study evaluates the impact of four emulsifiers on the characteristics of polyurethane hollow structures used as drug delivery system. Results Polyurethane (PU) structures with high stability and sizes ranging from nano- to micro-scale were obtained by interfacial polyaddition combined with spontaneous emulsification. The pH of PU aqueous solutions (0.1% w/w) was slightly acidic, which is acceptable for products intended to be used on human skin. Agglomerated structures with irregular shapes were observed by scanning electron microscopy. The synthesized structures have melting points between 245-265°C and reveal promising results in different evaluations (TEWL, mexametry) on murine skin. Conclusions In this study hollow PU structures of reduced noxiousness were synthesized, their size and stability being influenced by emulsifiers. Such structures could be used in the pharmaceutical field as future drug delivery systems.</description><identifier>ISSN: 1752-153X</identifier><identifier>EISSN: 1752-153X</identifier><identifier>EISSN: 2661-801X</identifier><identifier>DOI: 10.1186/1752-153X-7-66</identifier><identifier>PMID: 23575277</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Agglomeration ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Dispersions ; Drug delivery systems ; Emulsifiers ; Emulsion polymerization ; Materials and Polymers ; Nanostructure ; Polyurethane resins ; Research Article ; Stability</subject><ispartof>BMC chemistry, 2013-04, Vol.7 (1), p.66-66, Article 66</ispartof><rights>Heghes et al.; licensee Chemistry Central Ltd. 2013. This article is published under license to BioMed Central Ltd. 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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Heghes et al.; licensee Chemistry Central Ltd. 2013 Heghes et al.; licensee Chemistry Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b549t-609ee8edc4cc8dd94f78e46ac830daa66361eb8b081ad78f76790966ec0296983</citedby><cites>FETCH-LOGICAL-b549t-609ee8edc4cc8dd94f78e46ac830daa66361eb8b081ad78f76790966ec0296983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1347007964/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1347007964?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,25736,27907,27908,36995,44573,53774,53776,74877</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23575277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heghes, Alina</creatorcontrib><creatorcontrib>Soica, Codruta M</creatorcontrib><creatorcontrib>Ardelean, Simona</creatorcontrib><creatorcontrib>Ambrus, Rita</creatorcontrib><creatorcontrib>Muntean, Danina</creatorcontrib><creatorcontrib>Galuscan, Atena</creatorcontrib><creatorcontrib>Dragos, Dan</creatorcontrib><creatorcontrib>Ionescu, Daniela</creatorcontrib><creatorcontrib>Borcan, Florin</creatorcontrib><title>Influence of emulsifiers on the characteristics of polyurethane structures used as drug carrier</title><title>BMC chemistry</title><addtitle>Chemistry Central Journal</addtitle><addtitle>Chem Cent J</addtitle><description>Background Emulsifiers have a significant role in the emulsion polymerization by reducing the interfacial tension thus increasing the stability of colloidal dispersions of polymer nanostructures. This study evaluates the impact of four emulsifiers on the characteristics of polyurethane hollow structures used as drug delivery system. Results Polyurethane (PU) structures with high stability and sizes ranging from nano- to micro-scale were obtained by interfacial polyaddition combined with spontaneous emulsification. The pH of PU aqueous solutions (0.1% w/w) was slightly acidic, which is acceptable for products intended to be used on human skin. Agglomerated structures with irregular shapes were observed by scanning electron microscopy. The synthesized structures have melting points between 245-265°C and reveal promising results in different evaluations (TEWL, mexametry) on murine skin. Conclusions In this study hollow PU structures of reduced noxiousness were synthesized, their size and stability being influenced by emulsifiers. 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This study evaluates the impact of four emulsifiers on the characteristics of polyurethane hollow structures used as drug delivery system. Results Polyurethane (PU) structures with high stability and sizes ranging from nano- to micro-scale were obtained by interfacial polyaddition combined with spontaneous emulsification. The pH of PU aqueous solutions (0.1% w/w) was slightly acidic, which is acceptable for products intended to be used on human skin. Agglomerated structures with irregular shapes were observed by scanning electron microscopy. The synthesized structures have melting points between 245-265°C and reveal promising results in different evaluations (TEWL, mexametry) on murine skin. Conclusions In this study hollow PU structures of reduced noxiousness were synthesized, their size and stability being influenced by emulsifiers. 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subjects Agglomeration
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Dispersions
Drug delivery systems
Emulsifiers
Emulsion polymerization
Materials and Polymers
Nanostructure
Polyurethane resins
Research Article
Stability
title Influence of emulsifiers on the characteristics of polyurethane structures used as drug carrier
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