Pluripotent stem cells: immune to the immune system?

Human embryonic stem cells (hESCs), initially thought to be immune privileged cells, are now known to be susceptible to immune recognition. Human induced pluripotent stem cells (iPSCs) have been proposed as a potential source of autologous stem cells for therapy, but even these autologous stem cells...

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Bibliographic Details
Published in:Science translational medicine 2012-12, Vol.4 (164), p.164ps25-164ps25
Main Authors: Pearl, Jeremy I, Kean, Leslie S, Davis, Mark M, Wu, Joseph C
Format: Article
Language:English
Subjects:
Embryonic Stem Cells - cytology
Embryonic Stem Cells - immunology
HLA Antigens - immunology
Humans
Immune System - immunology
Immunity - immunology
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - immunology
Stem Cell Transplantation
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Summary:Human embryonic stem cells (hESCs), initially thought to be immune privileged cells, are now known to be susceptible to immune recognition. Human induced pluripotent stem cells (iPSCs) have been proposed as a potential source of autologous stem cells for therapy, but even these autologous stem cells may be targets of immune rejection. With clinical trials on the horizon, it is imperative that the immunogenicity of hESCs and iPSCs be definitively understood.
ISSN:1946-6234
1946-6242
DOI:10.1126/scitranslmed.3005090