Dissociation of Eye and Head Components of Gaze Shifts by Stimulation of the Omnipause Neuron Region

1 Departments of Otolaryngology, Neuroscience, and Bioengineering, Center for the Neural Basis of Cognition, University of Pittsburgh, Pennsylvania; and 2 Department of Neuroscience, Baylor College of Medicine, Houston, Texas Submitted 6 March 2007; accepted in final form 4 May 2007 Natural movement...

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Bibliographic Details
Published in:Journal of neurophysiology 2007-07, Vol.98 (1), p.360-373
Main Authors: Gandhi, Neeraj J, Sparks, David L
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Attention - physiology
Behavior, Animal
Electric Stimulation
Eye Movements - physiology
Fixation, Ocular - physiology
Head Movements - physiology
Macaca mulatta
Models, Biological
Motor Neurons - physiology
Pons - cytology
Reaction Time - physiology
Reaction Time - radiation effects
Statistics, Nonparametric
Time Factors
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Summary:1 Departments of Otolaryngology, Neuroscience, and Bioengineering, Center for the Neural Basis of Cognition, University of Pittsburgh, Pennsylvania; and 2 Department of Neuroscience, Baylor College of Medicine, Houston, Texas Submitted 6 March 2007; accepted in final form 4 May 2007 Natural movements often include actions integrated across multiple effectors. Coordinated eye-head movements are driven by a command to shift the line of sight by a desired displacement vector. Yet because extraocular and neck motoneurons are separate entities, the gaze shift command must be separated into independent signals for eye and head movement control. We report that this separation occurs, at least partially, at or before the level of pontine omnipause neurons (OPNs). Stimulation of the OPNs prior to and during gaze shifts temporally decoupled the eye and head components by inhibiting gaze and eye saccades. In contrast, head movements were consistently initiated before gaze onset, and ongoing head movements continued along their trajectories, albeit with some characteristic modulations. After stimulation offset, a gaze shift composed of an eye saccade, and a reaccelerated head movement was produced to preserve gaze accuracy. We conclude that signals subject to OPN inhibition produce the eye-movement component of a coordinated eye-head gaze shift and are not the only signals involved in the generation of the head component of the gaze shift. Address for reprint requests and other correspondence: N. J. Gandhi, 203 Lothrop St., Eye and Ear Institute, Rm. 108, University of Pittsburgh, Pittsburgh, PA 15213
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.00252.2007