Association of Arg194Trp, Arg280His and Arg399Gln polymorphisms in X-ray repair cross-complementing group 1 gene and risk of differentiated thyroid carcinoma in Iran

X-ray repair cross-complementing group 1 (XRCC1) gene is a DNA repair gene and its non-synonymous single nucleotide polymorphisms (SNP) may influence DNA repair capacity which has been considered as a modifying risk factor for cancer development. A case-control study was conducted to investigate imp...

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Published in:Iranian biomedical journal 2011-07, Vol.15 (3), p.73-78
Main Authors: Fard-Esfahani, Pezhman, Fard-Esfahani, Armaghan, Fayaz, Shima, Ghanbarzadeh, Bahareh, Saidi, Parinaz, Mohabati, Reyhaneh, Bidoki, Seyed Kazem, Majdi, Mina
Format: Article
Language:English
Subjects:
Arginine - genetics
Base Sequence
Case-Control Studies
Cell Differentiation
DNA Primers
Female
Genetic Complementation Test
Glycine - genetics
Histidine - genetics
Humans
Iran - epidemiology
Male
Middle Aged
Original
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Risk Factors
Thyroid Neoplasms - epidemiology
Thyroid Neoplasms - genetics
Thyroid Neoplasms - pathology
Tryptophan - genetics
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Summary:X-ray repair cross-complementing group 1 (XRCC1) gene is a DNA repair gene and its non-synonymous single nucleotide polymorphisms (SNP) may influence DNA repair capacity which has been considered as a modifying risk factor for cancer development. A case-control study was conducted to investigate impact of three frequently studied polymorphisms (Arg194Trp, Arg280His and Arg399Gln) on developing differentiated thyroid carcinoma (DTC). Increased risks for DTC were shown in homozygous (odds ratio [OR]: 3.66, 95% confidence interval [CI]: 0.38-35.60) and in dominant trait (OR: 1.22, 95% CI: 1.64-2.32) of Arg194Trp genotype. Also, for Arg280His genotype, an increased risk for DTC was shown in dominant trait (OR: 1.42, 95% confidence interval [CI]: 0.76-2.68), while a mildly reduction of risk for DTC (OR: 0.77, 95% [CI]: 0.50-1.17) was estimated in dominant Gln genotype of Arg399Gln. Considering combinatory effects of Arg194Trp and Arg280His genotypes on DTC, the calculated OR and 95% CI for being heterozygous for one of Arg194Trp or Arg280His genotypes were 1.57 and 0.90-2.74, respectively. Genotyping of codons 194, 280 and 399 in XRCC1 gene may use in risk assessment of DTC.
ISSN:1028-852X
2008-823X