Loading…
High- and Low-Fat Dairy Intake, Recurrence, and Mortality After Breast Cancer Diagnosis
Dietary fat in dairy is a source of estrogenic hormones and may be related to worse breast cancer survival. We evaluated associations between high- and low-fat dairy intake, recurrence, and mortality after breast cancer diagnosis. We included 1893 women from the Life After Cancer Epidemiology study...
Saved in:
| Published in: | JNCI : Journal of the National Cancer Institute 2013-05, Vol.105 (9), p.616-623 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c472t-e128063de06dc00f0c4647b956c4d1f92efe16da91577b791b25dd2da682bfff3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c472t-e128063de06dc00f0c4647b956c4d1f92efe16da91577b791b25dd2da682bfff3 |
| container_end_page | 623 |
| container_issue | 9 |
| container_start_page | 616 |
| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 105 |
| creator | KROENKE, Candyce H KWAN, Marilyn L SWEENEY, Carol CASTILLO, Adrienne CAAN, Bette J |
| description | Dietary fat in dairy is a source of estrogenic hormones and may be related to worse breast cancer survival. We evaluated associations between high- and low-fat dairy intake, recurrence, and mortality after breast cancer diagnosis.
We included 1893 women from the Life After Cancer Epidemiology study diagnosed with early-stage invasive breast cancer from 1997 to 2000, who completed the Fred Hutchinson Cancer Research Center Food Frequency Questionnaire after diagnosis. A total of 349 women had a recurrence and 372 died during a median follow-up of 11.8 years, with 189 deaths from breast cancer. We used delayed entry Cox proportional hazards regression to evaluate associations between categories of the cumulative average of dairy fat at baseline and at follow-up 5 to 6 years later and subsequent outcomes. Tests of statistical significance were two-sided.
In multivariable-adjusted analyses, overall dairy intake was unrelated to breast cancer-specific outcomes, although it was positively related to overall mortality. Low-fat dairy intake was unrelated to recurrence or survival. However, high-fat dairy intake was positively associated with outcomes. Compared with the reference (0 to |
| doi_str_mv | 10.1093/jnci/djt027 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3639864</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2974756921</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-e128063de06dc00f0c4647b956c4d1f92efe16da91577b791b25dd2da682bfff3</originalsourceid><addsrcrecordid>eNpd0VtrHCEYBmApLc0m7VXvy0ApFNJpPI2ON4V0kzSBDYHS0ktxPGzczmqiTsr--7rsNj0ooujDh_oC8ArBDwgKcrIK2p-YVYGYPwEzRBlsMYLdUzCDdavte04PwGHOK1ibwPQ5OMCEijrYDHy_9MvbtlHBNIv4s71QpTlTPm2aq1DUD_u--WL1lJINuq636jqmokZfNs2pKzY1n5JVuTRzVUVqzrxahph9fgGeOTVm-3I_H4FvF-df55ft4ubz1fx00WrKcWktwj1kxFjIjIbQQU0Z5YPomKYGOYGts4gZJVDH-cAFGnBnDDaK9XhwzpEj8HFX924a1tZoG0pSo7xLfq3SRkbl5b8nwd_KZXyQhBHRM1oLvNsXSPF-srnItc_ajqMKNk5ZItIxgWtHlb75j67ilEJ93lYR1LOekaqOd0qnmHOy7vEyCMptYHIbmNwFVvXrv-__aH8nVMHbPVBZq9Gl-tE-_3GcsF50nPwClkue3w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1353186863</pqid></control><display><type>article</type><title>High- and Low-Fat Dairy Intake, Recurrence, and Mortality After Breast Cancer Diagnosis</title><source>Oxford Journals Online</source><creator>KROENKE, Candyce H ; KWAN, Marilyn L ; SWEENEY, Carol ; CASTILLO, Adrienne ; CAAN, Bette J</creator><creatorcontrib>KROENKE, Candyce H ; KWAN, Marilyn L ; SWEENEY, Carol ; CASTILLO, Adrienne ; CAAN, Bette J</creatorcontrib><description>Dietary fat in dairy is a source of estrogenic hormones and may be related to worse breast cancer survival. We evaluated associations between high- and low-fat dairy intake, recurrence, and mortality after breast cancer diagnosis.
We included 1893 women from the Life After Cancer Epidemiology study diagnosed with early-stage invasive breast cancer from 1997 to 2000, who completed the Fred Hutchinson Cancer Research Center Food Frequency Questionnaire after diagnosis. A total of 349 women had a recurrence and 372 died during a median follow-up of 11.8 years, with 189 deaths from breast cancer. We used delayed entry Cox proportional hazards regression to evaluate associations between categories of the cumulative average of dairy fat at baseline and at follow-up 5 to 6 years later and subsequent outcomes. Tests of statistical significance were two-sided.
In multivariable-adjusted analyses, overall dairy intake was unrelated to breast cancer-specific outcomes, although it was positively related to overall mortality. Low-fat dairy intake was unrelated to recurrence or survival. However, high-fat dairy intake was positively associated with outcomes. Compared with the reference (0 to <0.5 servings/day), those consuming larger amounts of high-fat dairy had higher breast cancer mortality (0.5 to <1.0 servings/day: hazard ratio [HR] = 1.20, 95% confidence interval [CI] = 0.82 to 1.77; and ≥1.0 servings/day: HR = 1.49, 95% CI = 1.00 to 2.24, P trend = .05), higher all-cause mortality (P trend < .001), and higher non-breast cancer mortality (P trend = .007); the relationship with breast cancer recurrence was positive but not statistically significant. The higher risk appeared consistent across different types of high-fat dairy products.
Intake of high-fat dairy, but not low-fat dairy, was related to a higher risk of mortality after breast cancer diagnosis.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/djt027</identifier><identifier>PMID: 23492346</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - blood ; Breast Neoplasms - diagnosis ; Breast Neoplasms - etiology ; Breast Neoplasms - mortality ; California - epidemiology ; Carcinoma, Ductal, Breast - blood ; Carcinoma, Ductal, Breast - diagnosis ; Carcinoma, Ductal, Breast - etiology ; Carcinoma, Ductal, Breast - mortality ; Dairy products ; Dairy Products - adverse effects ; Diet - adverse effects ; Dietary Fats - administration & dosage ; Dietary Fats - adverse effects ; Estrogens - blood ; Feeding Behavior ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Incidence ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Mortality ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Recurrence, Local - diagnosis ; Neoplasm Recurrence, Local - etiology ; Neoplasm Recurrence, Local - mortality ; Odds Ratio ; Risk Assessment ; Risk Factors ; Tumors</subject><ispartof>JNCI : Journal of the National Cancer Institute, 2013-05, Vol.105 (9), p.616-623</ispartof><rights>2014 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) May 1, 2013</rights><rights>The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-e128063de06dc00f0c4647b956c4d1f92efe16da91577b791b25dd2da682bfff3</citedby><cites>FETCH-LOGICAL-c472t-e128063de06dc00f0c4647b956c4d1f92efe16da91577b791b25dd2da682bfff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27368957$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23492346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KROENKE, Candyce H</creatorcontrib><creatorcontrib>KWAN, Marilyn L</creatorcontrib><creatorcontrib>SWEENEY, Carol</creatorcontrib><creatorcontrib>CASTILLO, Adrienne</creatorcontrib><creatorcontrib>CAAN, Bette J</creatorcontrib><title>High- and Low-Fat Dairy Intake, Recurrence, and Mortality After Breast Cancer Diagnosis</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>J Natl Cancer Inst</addtitle><description>Dietary fat in dairy is a source of estrogenic hormones and may be related to worse breast cancer survival. We evaluated associations between high- and low-fat dairy intake, recurrence, and mortality after breast cancer diagnosis.
We included 1893 women from the Life After Cancer Epidemiology study diagnosed with early-stage invasive breast cancer from 1997 to 2000, who completed the Fred Hutchinson Cancer Research Center Food Frequency Questionnaire after diagnosis. A total of 349 women had a recurrence and 372 died during a median follow-up of 11.8 years, with 189 deaths from breast cancer. We used delayed entry Cox proportional hazards regression to evaluate associations between categories of the cumulative average of dairy fat at baseline and at follow-up 5 to 6 years later and subsequent outcomes. Tests of statistical significance were two-sided.
In multivariable-adjusted analyses, overall dairy intake was unrelated to breast cancer-specific outcomes, although it was positively related to overall mortality. Low-fat dairy intake was unrelated to recurrence or survival. However, high-fat dairy intake was positively associated with outcomes. Compared with the reference (0 to <0.5 servings/day), those consuming larger amounts of high-fat dairy had higher breast cancer mortality (0.5 to <1.0 servings/day: hazard ratio [HR] = 1.20, 95% confidence interval [CI] = 0.82 to 1.77; and ≥1.0 servings/day: HR = 1.49, 95% CI = 1.00 to 2.24, P trend = .05), higher all-cause mortality (P trend < .001), and higher non-breast cancer mortality (P trend = .007); the relationship with breast cancer recurrence was positive but not statistically significant. The higher risk appeared consistent across different types of high-fat dairy products.
Intake of high-fat dairy, but not low-fat dairy, was related to a higher risk of mortality after breast cancer diagnosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - etiology</subject><subject>Breast Neoplasms - mortality</subject><subject>California - epidemiology</subject><subject>Carcinoma, Ductal, Breast - blood</subject><subject>Carcinoma, Ductal, Breast - diagnosis</subject><subject>Carcinoma, Ductal, Breast - etiology</subject><subject>Carcinoma, Ductal, Breast - mortality</subject><subject>Dairy products</subject><subject>Dairy Products - adverse effects</subject><subject>Diet - adverse effects</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - adverse effects</subject><subject>Estrogens - blood</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Incidence</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Neoplasm Recurrence, Local - etiology</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Odds Ratio</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpd0VtrHCEYBmApLc0m7VXvy0ApFNJpPI2ON4V0kzSBDYHS0ktxPGzczmqiTsr--7rsNj0ooujDh_oC8ArBDwgKcrIK2p-YVYGYPwEzRBlsMYLdUzCDdavte04PwGHOK1ibwPQ5OMCEijrYDHy_9MvbtlHBNIv4s71QpTlTPm2aq1DUD_u--WL1lJINuq636jqmokZfNs2pKzY1n5JVuTRzVUVqzrxahph9fgGeOTVm-3I_H4FvF-df55ft4ubz1fx00WrKcWktwj1kxFjIjIbQQU0Z5YPomKYGOYGts4gZJVDH-cAFGnBnDDaK9XhwzpEj8HFX924a1tZoG0pSo7xLfq3SRkbl5b8nwd_KZXyQhBHRM1oLvNsXSPF-srnItc_ajqMKNk5ZItIxgWtHlb75j67ilEJ93lYR1LOekaqOd0qnmHOy7vEyCMptYHIbmNwFVvXrv-__aH8nVMHbPVBZq9Gl-tE-_3GcsF50nPwClkue3w</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>KROENKE, Candyce H</creator><creator>KWAN, Marilyn L</creator><creator>SWEENEY, Carol</creator><creator>CASTILLO, Adrienne</creator><creator>CAAN, Bette J</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20130501</creationdate><title>High- and Low-Fat Dairy Intake, Recurrence, and Mortality After Breast Cancer Diagnosis</title><author>KROENKE, Candyce H ; KWAN, Marilyn L ; SWEENEY, Carol ; CASTILLO, Adrienne ; CAAN, Bette J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-e128063de06dc00f0c4647b956c4d1f92efe16da91577b791b25dd2da682bfff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - etiology</topic><topic>Breast Neoplasms - mortality</topic><topic>California - epidemiology</topic><topic>Carcinoma, Ductal, Breast - blood</topic><topic>Carcinoma, Ductal, Breast - diagnosis</topic><topic>Carcinoma, Ductal, Breast - etiology</topic><topic>Carcinoma, Ductal, Breast - mortality</topic><topic>Dairy products</topic><topic>Dairy Products - adverse effects</topic><topic>Diet - adverse effects</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - adverse effects</topic><topic>Estrogens - blood</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Incidence</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Neoplasm Recurrence, Local - etiology</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Odds Ratio</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KROENKE, Candyce H</creatorcontrib><creatorcontrib>KWAN, Marilyn L</creatorcontrib><creatorcontrib>SWEENEY, Carol</creatorcontrib><creatorcontrib>CASTILLO, Adrienne</creatorcontrib><creatorcontrib>CAAN, Bette J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KROENKE, Candyce H</au><au>KWAN, Marilyn L</au><au>SWEENEY, Carol</au><au>CASTILLO, Adrienne</au><au>CAAN, Bette J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High- and Low-Fat Dairy Intake, Recurrence, and Mortality After Breast Cancer Diagnosis</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>105</volume><issue>9</issue><spage>616</spage><epage>623</epage><pages>616-623</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><coden>JNCIEQ</coden><abstract>Dietary fat in dairy is a source of estrogenic hormones and may be related to worse breast cancer survival. We evaluated associations between high- and low-fat dairy intake, recurrence, and mortality after breast cancer diagnosis.
We included 1893 women from the Life After Cancer Epidemiology study diagnosed with early-stage invasive breast cancer from 1997 to 2000, who completed the Fred Hutchinson Cancer Research Center Food Frequency Questionnaire after diagnosis. A total of 349 women had a recurrence and 372 died during a median follow-up of 11.8 years, with 189 deaths from breast cancer. We used delayed entry Cox proportional hazards regression to evaluate associations between categories of the cumulative average of dairy fat at baseline and at follow-up 5 to 6 years later and subsequent outcomes. Tests of statistical significance were two-sided.
In multivariable-adjusted analyses, overall dairy intake was unrelated to breast cancer-specific outcomes, although it was positively related to overall mortality. Low-fat dairy intake was unrelated to recurrence or survival. However, high-fat dairy intake was positively associated with outcomes. Compared with the reference (0 to <0.5 servings/day), those consuming larger amounts of high-fat dairy had higher breast cancer mortality (0.5 to <1.0 servings/day: hazard ratio [HR] = 1.20, 95% confidence interval [CI] = 0.82 to 1.77; and ≥1.0 servings/day: HR = 1.49, 95% CI = 1.00 to 2.24, P trend = .05), higher all-cause mortality (P trend < .001), and higher non-breast cancer mortality (P trend = .007); the relationship with breast cancer recurrence was positive but not statistically significant. The higher risk appeared consistent across different types of high-fat dairy products.
Intake of high-fat dairy, but not low-fat dairy, was related to a higher risk of mortality after breast cancer diagnosis.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>23492346</pmid><doi>10.1093/jnci/djt027</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 2013-05, Vol.105 (9), p.616-623 |
| issn | 0027-8874 1460-2105 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3639864 |
| source | Oxford Journals Online |
| subjects | Adult Aged Biological and medical sciences Breast cancer Breast Neoplasms - blood Breast Neoplasms - diagnosis Breast Neoplasms - etiology Breast Neoplasms - mortality California - epidemiology Carcinoma, Ductal, Breast - blood Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - etiology Carcinoma, Ductal, Breast - mortality Dairy products Dairy Products - adverse effects Diet - adverse effects Dietary Fats - administration & dosage Dietary Fats - adverse effects Estrogens - blood Feeding Behavior Female Gynecology. Andrology. Obstetrics Humans Incidence Mammary gland diseases Medical sciences Middle Aged Mortality Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - etiology Neoplasm Recurrence, Local - mortality Odds Ratio Risk Assessment Risk Factors Tumors |
| title | High- and Low-Fat Dairy Intake, Recurrence, and Mortality After Breast Cancer Diagnosis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T01%3A53%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High-%20and%20Low-Fat%20Dairy%20Intake,%20Recurrence,%20and%20Mortality%20After%20Breast%20Cancer%20Diagnosis&rft.jtitle=JNCI%20:%20Journal%20of%20the%20National%20Cancer%20Institute&rft.au=KROENKE,%20Candyce%20H&rft.date=2013-05-01&rft.volume=105&rft.issue=9&rft.spage=616&rft.epage=623&rft.pages=616-623&rft.issn=0027-8874&rft.eissn=1460-2105&rft.coden=JNCIEQ&rft_id=info:doi/10.1093/jnci/djt027&rft_dat=%3Cproquest_pubme%3E2974756921%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c472t-e128063de06dc00f0c4647b956c4d1f92efe16da91577b791b25dd2da682bfff3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1353186863&rft_id=info:pmid/23492346&rfr_iscdi=true |