Gene Copy-Number Alterations: A Cost-Benefit Analysis

Changes in DNA copy number, whether confined to specific genes or affecting whole chromosomes, have been identified as causes of diseases and developmental abnormalities and as sources of adaptive potential. Here, we discuss the costs and benefits of DNA copy-number alterations. Changes in DNA copy...

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Bibliographic Details
Published in:Cell 2013-01, Vol.152 (3), p.394-405
Main Authors: Tang, Yun-Chi, Amon, Angelika
Format: Article
Language:English
Subjects:
abnormal development
Aneuploidy
Animals
chromosomes
cost benefit analysis
DNA
DNA Copy Number Variations
Gene Dosage
Gene Expression
genes
Genetic Fitness
human diseases
Humans
microorganisms
Neoplasms - genetics
phenotype
Plants - genetics
Polyploidy
Yeasts - genetics
Yeasts - physiology
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Summary:Changes in DNA copy number, whether confined to specific genes or affecting whole chromosomes, have been identified as causes of diseases and developmental abnormalities and as sources of adaptive potential. Here, we discuss the costs and benefits of DNA copy-number alterations. Changes in DNA copy number are largely detrimental. Amplifications or deletions of specific genes can elicit discrete defects. Large-scale changes in DNA copy number can also cause detrimental phenotypes that are due to the cumulative effects of copy-number alterations of many genes simultaneously. On the other hand, studies in microorganisms show that DNA copy-number alterations can be beneficial, increasing survival under selective pressure. As DNA copy-number alterations underlie many human diseases, we will end with a discussion of gene copy-number changes as therapeutic targets.
ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2012.11.043