Systemic immune system alterations in early stages of Alzheimer's disease

Abstract Immune activation and inflammation play significant roles in the pathogenesis of Alzheimer's disease (AD). To test whether AD patients showed systemic manifestations of inflammation, blood from 41 patients with early stages of AD and 31 aged-match elderly controls were evaluated. Cellu...

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Bibliographic Details
Published in:Journal of neuroimmunology 2013-03, Vol.256 (1), p.38-42
Main Authors: Zhang, Rongzhen, Miller, Robert G, Madison, Catherine, Jin, Xia, Honrada, Ronald, Harris, Will, Katz, Jonathan, Forshew, Dallas A, McGrath, Michael S
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Allergy and Immunology
Alzheimer Disease - immunology
Alzheimer Disease - physiopathology
Alzheimer's disease
Case-Control Studies
Chemokine CCL2 - blood
Cross-Sectional Studies
Cytokines - blood
Enzyme-Linked Immunosorbent Assay - methods
Female
Flow Cytometry
Humans
Immune System - metabolism
Immunoglobulin G - blood
Immunoglobulin M - blood
Macrophage Activation
Male
Middle Aged
Monocyte chemoattractant protein-1 (MCP-1)
Monocyte/macrophage (MO)
Monocytes - metabolism
Neurology
Systemic immune activation/inflammation
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Summary:Abstract Immune activation and inflammation play significant roles in the pathogenesis of Alzheimer's disease (AD). To test whether AD patients showed systemic manifestations of inflammation, blood from 41 patients with early stages of AD and 31 aged-match elderly controls were evaluated. Cellular markers for monocyte/macrophage (MO) activation and CD8 T lymphocyte were increased in early AD patients. Expression of monocyte CCR2, the receptor for monocyte chemoattractant protein-1 (MCP-1), was decreased; however, plasma MCP-1 levels were significantly increased and were related to the degree of MO activation in AD. These findings suggest that AD pathogenesis may be influenced by systemic immunologic dysfunction and provides potential immunologic targets for therapeutic intervention.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2013.01.002