PCBs and OH-PCBs in Serum from Children and Mothers in Urban and Rural U.S. Communities

East Chicago, Indiana is a heavily industrialized community bisected by the Indiana Harbor and Ship Canal, which volatilizes ∼7.5 kg/yr polychlorinated biphenyls (PCBs). In contrast, the rural Columbus Junction, Iowa area has no known current or past PCB industrial sources. Blood from children and t...

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Bibliographic Details
Published in:Environmental science & technology 2013-04, Vol.47 (7), p.3353-3361
Main Authors: Marek, Rachel F, Thorne, Peter S, Wang, Kai, DeWall, Jeanne, Hornbuckle, Keri C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Child
Children & youth
Human exposure
Humans
Hydroxylation
Linear Models
Medical sciences
Molecular Weight
Mothers
PCB
Polychlorinated biphenyls
Polychlorinated Biphenyls - blood
Polychlorinated Biphenyls - chemistry
Rural areas
Rural Population
Toxicology
United States
Urban Population
Various organic compounds
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Summary:East Chicago, Indiana is a heavily industrialized community bisected by the Indiana Harbor and Ship Canal, which volatilizes ∼7.5 kg/yr polychlorinated biphenyls (PCBs). In contrast, the rural Columbus Junction, Iowa area has no known current or past PCB industrial sources. Blood from children and their mothers from these communities were collected April 2008 to January 2009 (n = 177). Sera were analyzed for all 209 PCBs and 4 hydroxylated PCBs (OH-PCBs). Sum PCBs ranged from nondetect to 658 ng/g lw (median = 33.5 ng/g lw). Sum OH-PCBs ranged from nondetect to 1.2 ng/g fw (median = 0.07 ng/g fw). These concentrations are similar to those reported in other populations without high dietary PCB intake. Differences between the two communities were subtle. PCBs were detected in more East Chicago mothers and children than Columbus Junction mothers and children, and children from East Chicago were enriched in lower-molecular weight PCBs. East Chicago and Columbus Junction residents had similar levels of total and individual PCBs and OH-PCBs in their blood. Concentrations of parent PCBs correlated with concentrations of OH-PCBs. This is the first temporally and methodologically consistent study to evaluate all 209 PCBs and major metabolites in two generations of people living in urban and rural areas of the United States.
ISSN:0013-936X
1520-5851
DOI:10.1021/es304455k